microcytic anemias

Question 1

percent of sample occupied by red cells

Answer 1

hematocrit

Question 2

mean amount of vol contained in RBC

Answer 2

mean corpuscular vol

Question 3

amt of hemoglobin (mass) per RBC

Answer 3

mean corpuscular hemoglobin

Question 4

ration of amt of hemoglobin in average cell to the amt of vol

Answer 4

mean corpuscular HgB concentration

Question 5

MCV is mainly used to classify

Answer 5

anemias

Question 6

microcytic anemias usually due to

Answer 6

decreased hemoglobin in red cells

Question 7

hemoglobin components

Answer 7

1. globin chains
2. protoporphyrin
3. iron

Question 8

heme iron is found in

Answer 8

meats, easily abs

Question 9

non heme iron

Answer 9

absorbed in Fe2+ state, aided by vit C

Question 10

uptake of iron to plasma regulated by

Answer 10

enterocytes

Question 11

iron transporter

Answer 11

ferroportin

Question 12

iron transport protein

Answer 12

transferrin

Question 13

iron storage protein

Answer 13

ferritin

Question 14

what happened to transferrin when iron stores are low

Answer 14

increased

Question 15

total iron binding capacity

Answer 15

amt of transferrin in serum

Question 16

serum ferritin

Answer 16

amt of storage iron

Question 17

iron def can be seen in

Answer 17

babies

Question 18

adult or post-menopausal female with iron def must have work up for

Answer 18

colon cancer

Question 19

__ can also be a cause of iron def

Answer 19

preg

Question 20

pregnancy and OCPs can increase

Answer 20

plasma transferrin

Question 21

how to diagnose iron def in pt with OCPs or preg

Answer 21

low ferritin

Question 22

rare causes of iron def

Answer 22

hookworms & Plummer vinson syndrome

Question 23

summary of iron def

Answer 23

decreased serum iron
decreased ferritin
increased transferrin
decreased saturation

Question 24

iron def produces what kind of anemia

Answer 24

microcytic hypochromic anemia

Question 25

red cell distribution width in iron def

Answer 25

increased

Question 26

erythrocyte protophorphyrin level in iron def

Answer 26

elevated

Question 27

iron def anemia treatment

Answer 27

iron supplementation

Question 28

anemia of chronic disease is associated with

Answer 28

inflammation

Question 29

anemia of chronic disease is triggered by

Answer 29

cytokines

Question 30

anemia of chronic disease has lack of availability of

Answer 30

iron

Question 31

key mediator in anemia of chronic disease

Answer 31

hepcidin

Question 32

hepcidin is a

Answer 32

acute phase protein

Question 33

hepcidin affects

Answer 33

iron metabolism

Question 34

hepcidin binds to

Answer 34

ferroportin in enterocytes and iron becomes trapped in cells

Question 35

key finding in anemia of chronic disease

Answer 35

increased ferritin

Question 36

diagnosis of anemia of chronic disease diagnosis

Answer 36

serum iron is low
ferritin increased
TIBC is decreased
saturation is normal

Question 37

lead poisoning inhibits

Answer 37

heme synthesis

Question 38

lead poisoning leads to build up of

Answer 38

delta ALA and protoporphyrin

Question 39

blood smear of lead poisoning

Answer 39

basophilic stippling due to accumulation of pyrimidines in RBCs

Question 40

lead poisoning sxs

Answer 40

abd pain, lead lines, foot drop

Question 41

children with lead poisoning may have

Answer 41

behavioral issues

Question 42

drugs for lead poisoning

Answer 42

dimercaprol
calcium disodium EDTA
DMSA

Question 43

sideroblast

Answer 43

red blood cell precursor

Question 44

sideroblastic anemia is due to

Answer 44

failure to make protoporphyrin leading to iron accumulation in mitochondria

Question 45

sideroblastic anemia is usually secondary due to

Answer 45

toxin

Question 46

x linked sideroblastic anemia causes

Answer 46

def of ALA synthase

Question 47

x linked sideroblastic anemia can be treated with

Answer 47

vit B6

Question 48

lab findings in sideroblastic anemia

Answer 48

low erythrocyte protoporphyrin levels