hypercoagulable states

Question 1

virchows triad

Answer 1

1. endothelial damage
2. stasis of blood
3. hypercoagulability

Question 2

hypercoagulable states include

Answer 2

post-op, fall, hip fracture, trauma, long plane flights, malignancy

Question 3

elevated homocysteine is associated with

Answer 3

arterial and venous clots

Question 4

homocysteine levels are lowered by

Answer 4

folate

Question 5

nephrotic syndrome is hypercoagulable state because loss

Answer 5

of anti-clotting factors in urine (antithrombin III)

Question 6

estrogen containing oral contraceptives are contraindicated if

Answer 6

age >35 and >15 cigs per day

Question 7

factor V leiden mut

Answer 7

factor V is not inactivated by activated protein C so factor V remains active longer

Question 8

factor V leiden mut is due to

Answer 8

point mutation in factor V gene

Question 9

prothrombin gene mutation

Answer 9

prothrombin 20210

Question 10

antithrombin III deficiency classically presents as

Answer 10

heparin resistance

Question 11

protein C def associated w

Answer 11

warfarin skin necrosis

Question 12

initial warfarin therapy is causes

Answer 12

decreased protein C but if already protein C def it is markedly decreased

Question 13

result of protein C def results in

Answer 13

thrombosis

Question 14

antiphospholipid syndrome occur in associated with

Answer 14

lupus

Question 15

3 imp clinical consequences of antibodies

Answer 15

1. increased risk of venous & arterial thrombosis
2. increased PTT
3. false positive syphilis

Question 16

venous and arterial thrombosis can cause

Answer 16

recurrent fetal loss

Question 17

antiphospholipid syndrome

Answer 17

1. anticardiolipin
2. lupus anticoagulant
3. anti-B2 glycoprotein

Question 18

anticardiolipin causes

Answer 18

false positive of syphilis

Question 19

lupus anticoagulant causes

Answer 19

false elevation of PTT

Question 20

lupus anticoagulant can be detected by

Answer 20

lupus anticoagulant