complement system

Question 1

C3 is synthesized by the

Answer 1

liver

Question 2

C3 is converted to

Answer 2

C3b

Question 3

C3b role

Answer 3

binds to bacteria causing death

Question 4

alternative pathway

Answer 4

C3 spontaneously converts to C3b

Question 5

surfaces that bind C3b making it stable

Answer 5

LPS
fungal cell walls
viral envelopes

Question 6

stable C3b can bind

Answer 6

complement protein b

Question 7

__ clips B bound to C3b

Answer 7

complement protein D

Question 8

when complement protein D clips B bound to C3b it forms

Answer 8

C3 convertase C3bBb

Question 9

role of C3 convertase

Answer 9

to cleave more C3 to C3b

Question 10

factor H is synthesized in

Answer 10

liver

Question 11

factor H blocks

Answer 11

alternative pathway on host cells

Question 12

mannose binding lectin is produced by

Answer 12

liver

Question 13

mannose binding lectin circulates with mannose associated serine proteases and binds

Answer 13

surfaces with mannose

Question 14

in the classical pathway C1 cleaves

Answer 14

C2 and C4

Question 15

when C1 cleaves C2 and C4 what forms

Answer 15

C2b4b convertase

Question 16

C2b4b role

Answer 16

coverts C3 to C3b

Question 17

__ is synthesized in the liver in response to IL-6

Answer 17

c reactive protein (acute phase reactant)

Question 18

c reative protein activates

Answer 18

classical pathway via C1 binding

Question 19

C3a role

Answer 19

anaphylatoxin (histamine release mast cells, increased vascular permeability)

Question 20

stable C3b leads to formation of

Answer 20

MAC

Question 21

MAC is formed from

Answer 21

C5-C9

Question 22

C5a role

Answer 22

anaphylatoxin, neutrophil chemotaxis

Question 23

membrane proteins that protect human cells

Answer 23

decay accelerating factor (DAF/CD55)
MAC inhibitory protein (CD59)

Question 24

DAF disrupts

Answer 24

C3b attachment

Question 25

CD59 disrupts

Answer 25

MAC

Question 26

CD55 and CD59 are especially imp for protecting

Answer 26

RBCs

Question 27

def of DAF or CD59 leads to

Answer 27

hemolysis

Question 28

paroxysmal nocturnal hemoglobinuria sxs

Answer 28

sudden hemolysis at night
anemia
abd pain
thrombosis

Question 29

paroxysmal nocturnal hemoglobinuria due to defect in

Answer 29

DAF/CD59

Question 30

inherited C3 def sxs

Answer 30

recurrent infections with encapsulated bacteria
immune complex deposition

Question 31

C5-C9 def sxs

Answer 31

impaired defense against encapsulated bugs (neisseria)

Question 32

hereditary angioedema due to def in

Answer 32

C1 inhibitor protein

Question 33

C1 breaks down

Answer 33

bradykinin (vasodilator)

Question 34

hereditary angioedema diagnosis

Answer 34

low C4 (due to lack of C1 inhibitor)

Question 35

never give __ to patients with hereditary angioedema

Answer 35

ACE inhibitor (leads to more build up bradykinin)

Question 36

C3 nephritic factor stabilizes

Answer 36

C3 convertase

Question 37

CH50 tests

Answer 37

classical pathway (need all compliment factors for normal result)