Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

boards and beyond > coagulation > Flashcards

coagulation Flashcards

1
Q

first line of defense against bleeding

A

vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

key mediator of vasoconstriction in response to endothelial damage

A

endothelins (proteins released by endothelial cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

coagulation factors are synthelized in the

A

liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

coagulation factors form

A

fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

coagulation factors circulate as

A

zymogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

many coagulation factors active to become

A

serine proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

center of coagulation cascade is activation of

A

X to Xa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Xa converts

A

prothrombin to thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

thrombin converts

A

fibrinogen to fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Xa inhibitors

A

rivaroxaban
apixaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

direct thrombin inhibitors

A

hirudin
lepirudin
bivalirudin
desirudin
argatroban
dabigatran

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

major activator of coagulation system

A

tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

primary event causes

A

exposure of tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

tissue factor interacts with

A

VII and activates it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

tissue factor and VIIa activate

A

X to Xa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

thrombin makes more

A

thrombin and acts as positive feedback for the cascade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

defects in factors IX and VIII cause

A

hemophilia (cant amply clotting cascade which causes bleeding)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

factor VIII circulates bound to

A

von Willebrand factor (which increases half life)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

factor VIII is produced in

A

endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

multicomponent complexes are three components bound together including

A
  1. active clotting factor
  2. co factor
  3. substrate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

multicomponent complexes require

A

phospholipids and calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

extrinsic Xase (multicomponent complex) enzyme

A

VIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

intrinsic Xase enzyme

A

IXa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

calcium is required for

A

clot formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

role of factor XIII

A

crosslinks fibrin stabilizing the plug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

factor XIII requires what as a cofactor

27
Q

XII is activated by

A

contact with negative charges (silica)

28
Q

basis for partial thromboplastin time

A

factor XII

29
Q

intrinsic pathway requires

30
Q

kinins link

A

coagulation with inflammation

31
Q

bradykinin

A

vasodilator

32
Q

bradykinin is degraded by

A

ACE & C1 inhibitor

33
Q

C1 inhibitor deficiency causes

A

hereditary angioedema

34
Q

factor XII activates

A

clotting and produces bradykinin

35
Q

prekallikrein deficiency results in

A

markedly prolonged PTT

36
Q

in prekallikrein deficiency __ cannot activate the clotting cascade normally

37
Q

kinin system activated by

A

factor XII

38
Q

imp deactivators of coagulation

A

antithrombin III
protein C and S
tissue factor pathway inhibitor

39
Q

antithrombin III is a

A

serpin (inhibitor of sarin proteases)

40
Q

antithrombin III inhibits

A

II, VII, IX, X, XI, XII

41
Q

antithrombin III is the basis for

A

heparin drug therapy

42
Q

deficiency antithrombin III causes

A

hypercoagulable state

43
Q

protein C and S are

A

glycoproteins synthesized in liver

44
Q

activated protein C inactivates factors

A

Va and VIIIa

45
Q

protein C activated by

A

thrombomodulin

46
Q

thrombomodulin binds

A

thrombin and then activates protein C

47
Q

activated protein C requires

A

protein S as a co factor

48
Q

tissue factor pathway inhibitor inactivates

49
Q

tissue factor pathway plasma levels increased with

A

heparin administration

50
Q

plasminogen is synthelized by

51
Q

plasminogen is converted to

A

active enzyme plasmin

52
Q

main role of plasmin

A

breakdown fibrin

53
Q

plasminogen activators

A

tissue plasminogen activator & urokinase

54
Q

fibrin is broken down into

A

fibrin degradation products & D dimer

55
Q

presence of D dimer indicates

A

clot breakdown

56
Q

fibrinogen degradation products indicate

A

plasmin activity only

57
Q

primary fibrinolysis is a rare phenomena in which

A

plasmin is overactive

58
Q

primary fibrinolysis causes

A

increased fibrin degradation products with normal D dimer

59
Q

plasmin can deplete

A

clotting factors

60
Q

clot breakdown causes

A

fibrinogen degradation products and dimers

61
Q

hyperfibrinolysis causes

A

fibrinogen degradation products and normal dimers

62
Q

vitamin K is required for

A

syntheisis of clotting factors II, VII, IX, X, C, S

63
Q

warfarin is a

A

vit k antagonist

64
Q

erythrocyte sedimentation rate is increased in

A

inflammatory conditions

boards and beyond (36 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions