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boards and beyond > glucocorticoids & nsaids > Flashcards

glucocorticoids & nsaids Flashcards

1
Q

lipids are turned into arachidonic acid by

A

phospholipase A2

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2
Q

arachidonic acid is turned into leukotrienes by

A

lipoxygenase

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3
Q

arachidonic is turned into thromboxanes & prostaglandins by

A

cyclooxygenase

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4
Q

cyclooxygenase has two

A

isoforms (COX1 & COX2)

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5
Q

COX1 role

A

imp for GI mucosal function

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6
Q

COX2 role

A

inducible in inflammatory cells

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7
Q

NSAIDS moa

A

reversibly inhibits COX1 & COX2

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8
Q

benefits of nsaids

A

decrease pain, redness, swelling

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9
Q

ADE of nsaids

A

decreased platelet aggregation
decreased renal blood flow
increased GI ulcers

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10
Q

acute interstitial nephritis is caused by

A

nsaids

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11
Q

acute interstitial nephritis

A

inflammation of interstium due to hypersensitivity allergic reaction

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12
Q

classic finding in acute interstitial nephritis

A

urine eosinophils

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13
Q

PGE2 role

A

vasodilation, fever, edema, pain, & renal vasodilation

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14
Q

PGE2/PGI2 role

A

protect GI mucosa

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15
Q

TXA2 role

A

platelet adhesion

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16
Q

LTC4/LTD4 role

A

vasodilators and bronchoconstriction (imp role in asthma)

17
Q

LTB4 role

A

neutrophils & eosinophils chemotaxis

18
Q

cox 2 inhibitor name

A

celecoxib

19
Q

cox 2 benefits

A

decreased pain, redness, bleeding
less risk of GI ulcers

20
Q

ADE of COX2

A

increased CV events

21
Q

COX1 main product

A

TXA2

22
Q

glucocorticoids MOA

A

inactivation of NF-KB

23
Q

inactivation of NF-KB causes

A

mediates response to TNF alpha
controls synthesis of inflammatory mediators (COX2, PLA2, lipoxygenase)

24
Q

effects of glucocorticoids

A

increase neutrophils
decrease cytokines & eosinophils

25
Q

side effects of glucocorticoids

A

skin thinning, easy bruising, hyperglycemia, osteoporosis, cushings

26
Q

major side effect of glucocorticoids

A

avascular necrosis

27
Q

avascular necrosis path

A

bone collapse due to interruption of blood flow & bone thinning

28
Q

long term steroid use suppresses

A

HPA axis

29
Q

abrupt discontinuation of steroids causes

A

adrenal gland insufficiency

30
Q

sxs of adrenal gland insufficiency

A

hypotension, shock, weakness, fatigue

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