transplants Flashcards
1
Q
for bone marrow transplants you must abolish
A
bone marrow with chemo
2
Q
autograft
A
done-recipient is same person
3
Q
syngenetic graft
A
identical twins
4
Q
xenograft
A
different species
5
Q
allograft
A
same species
6
Q
failure to match leads to
A
rejection of transplant
7
Q
features of good match
A
- same blood type
- same MHC
- negative cross match screen
8
Q
donor cells express MHC I, if different from recipient..
A
CD8 cells will react
9
Q
human leukocyte antigens make up
A
MHC class I and II molecules
10
Q
genes on chromosome __ determine HLA type
A
6
11
Q
some HLA subtypes are associated with
A
autoimmune disease
12
Q
__ sets of HLA genes per parent
A
2
13
Q
sibling has __ chance of match
A
25%
14
Q
most imp HLA genes for solid organ transplants
A
HLA-A
HLA-B
HLA-DR
15
Q
two problems with mismatch
A
- rejection of new cells
- graft vs host disease
