transplants

Question 1

for bone marrow transplants you must abolish

Answer 1

bone marrow with chemo

Question 2

autograft

Answer 2

done-recipient is same person

Question 3

syngenetic graft

Answer 3

identical twins

Question 4

xenograft

Answer 4

different species

Question 5

allograft

Answer 5

same species

Question 6

failure to match leads to

Answer 6

rejection of transplant

Question 7

features of good match

Answer 7

1. same blood type
2. same MHC
3. negative cross match screen

Question 8

donor cells express MHC I, if different from recipient..

Answer 8

CD8 cells will react

Question 9

human leukocyte antigens make up

Answer 9

MHC class I and II molecules

Question 10

genes on chromosome __ determine HLA type

Answer 10

6

Question 11

some HLA subtypes are associated with

Answer 11

autoimmune disease

Question 12

__ sets of HLA genes per parent

Answer 12

2

Question 13

sibling has __ chance of match

Answer 13

25%

Question 14

most imp HLA genes for solid organ transplants

Answer 14

HLA-A
HLA-B
HLA-DR

Question 15

two problems with mismatch

Answer 15

1. rejection of new cells
2. graft vs host disease

Question 16

path of graft vs host

Answer 16

donated T cells react with recipient cells

Question 17

sxs of graft vs host

Answer 17

rash, diarrhea, abd pain

Question 18

hyperacute rejection happens

Answer 18

within mins

Question 19

hyperacuture rejection is caused by

Answer 19

preformed antibodies in recipient

Question 20

hyperacute rejection sxs

Answer 20

blood vessel spasm
intravascular coag
ischemia

Question 21

acute rejection occurs

Answer 21

weeks to months after transplant

Question 22

path of acute rejection

Answer 22

recipient T cells react to graft causing cell mediated immune response

Question 23

biopsy of acute rejection shows

Answer 23

lymphocytes

Question 24

chronic rejection occurs

Answer 24

months to years after transplant

Question 25

chronic rejection shows

Answer 25

fibrosis of vessels