urinary incontinence Flashcards
over active bladder symptoms
urinary urgency with or without incontinence
urinary frequency >8 times
>2 times at night
urinary incontinence
what neurotransmitter is active in bladder
acH acting in muscuranic receptor working the parasympathitc nervous system
what receptor works in the bladder
M3 muscuranic
risk factors for overactive bladder
Age> 40
diabetes
vaginal delivery
obesity
neurologic conditions
and drugs- alcohol, cholinesterase inhibitors, sedatives and diuretics)
non drug tx
behavioral therapies
kegel, pelvic floor muscle
drug tx for OAB
anticholinergics 1st line
Beta 3 agonist
botox
what are the anticholinergics drugs
oxybutynin
tolterodine
solifenacin
darifenacin
fesoterodine
MOA of anticholinergics
antimuscaranic acrtivity blocks acetylcholine from binding
extended release is preffered over imediate release
selective M3 less AE
what are the selective M3 antagonists
solifenacin
darifenacin
festerodine
what are some AE for anticholinergics
dry mouth
dizziness
delerium and cognitive impairment >65 years age
urinary retention
dry eyes
constipation
what are some B3 agonists
mirabegron Myrbetriq
vibegron Gemtesa
MOA for B3 agonist
relaxes detrusor muscle and increase bladder capacity by activating B3 receptors
ess dry mouth than anticholinergics
what are some AE for B3 agonist
increase BP
urinary retention
what is a nocturia tx FDA approved
desmopressin tablet, antidiuretic hormone that decreases urine
what are some Warnings with Desmopressin
severe hyponatremia
fluid retention
