ID 1 part 3 Flashcards
gram positive antibiotics
vancomycin
lipoglycopeptides- tealvancin, oritavancin, dalbavancin
daptomycin
oxazolidiones - linezolid, tedizolid
quinupristin/dalfopristin
vancomycin
moa- Dalanyl D alanyl
PO- c diff
MRSA
not VRE
AE of vanc
otoxicity
nephrotoxic
red man syndrome
lipoglycopeptiteds
tmoa- bacterial cell wall synthesis inhibitor-Dalanyl Dalanin,disrupts membrane potential
Telavancin
ortia
dalbavancin
AE of lipoglycopeptides
teratogenic
same as vanc
daptomycin
MRSA VRE
AE- falsly elevate P/INR
increase CPK
compatible with NS
inactivated in lungs by surfactants
risk with statins
oxazolidiones
MOA- 50s ribosome synthesis blocker
linezolid
tedizolid
linezolid
MAO inhibitor 2 week wash out period
myelosupression while under linezolid
decrease platelete hgb WBC
increase LFTs
IV:PO 1:1
no renal adjustment
synercid
VRE
no renal adjustment
use with D5W
other broad spectrum
tigecycline
polymyxim
chloramphenicol
tigecycline
MOA- 30 s ribosome
kinda related to tetracycline
MRSA VRE
anerobes, atypicals
no activity against 3 Ps- pseudomonas protius providencia
AE with tigecycline
risk of death
not for BBP
can increase INR
polymyxim
nephrotoxic
neurotoxic
resiratory paralysis
used for MDR gram negatives - entero, klebsiella , pseudomonas
clindamycin
lincoasamide 50s ribosomes
for MRSA
dont use in C diff
metronidazole
do not use alcohol
anaerobe and protozaol function
bacterial vaginosis, trichomoniasis, cdiff
do not use in pregnancy 1st trimester
can cause metalic taste
rifaximin
travellers diarrhea
IBS D
hepatic encephalopathy
not effective for systemic infections
fidaxomicin
C diff
fosfomycin
E coli
VRE
uncomplicated UTI
nitrofurantoin
bacterial cell wall inhibitor
macrobid BID
GI upset
renail <60
mupirocin
topical MRSA
MMSA tx
nafcillin, oxacillin dicloxacillin
cefazolin cephalexin
amox.calvulanate, ampicillin
doxycycline, minocycline
SMX/TMP
MRSA hospital
vanc
linezolid
daptomycin
MRSA CA
SMX/TMP
doxy, mino
clinda
linezolid
severe SSTIs MRSA and strep
vanc
linezolid
dapto
ceftaroline
VRE
pen G
linezolid
dapto
HPNEK
beta lactam
SMX
aminoglycosides
cephalosporin other than 1st gen
quinolones
Atypical coverage
azithro, clarithro
doxy
quinolones
pseudomonas
piperacillin
cefepime
ceftazidime/avi
ceftolane/tazo
carbapenems except erta
cipro levo
aztreo
aminoglycosides
polymyxim
c diff
van
fidaxomicin
metronidazole
B fragilis
metro
beta lactam
cefotetan
carbapenems
CRE
ceftazidime/avibactam
polymyxim
meropenem
which abx doesnt reequire a renal dose
nafcicillin dicloxacillin
ceftraiaxone
clindamycin
doxycycline
macrolides matronidazole
moxifloxacin
linezolid
which abx is taken without food
mostly taken with food except
ampicillin oral suspension
levofloxacin
pen vk
rifampin
isoniazid
itraconazole
voriconazole
which drugs are 1:1 ration IV to PO
levo
linezolid
metronidazole
bactrim
fluconazole posaconazole
doxycycline, minocycline
which drugs need light protextion
doxycycline
micafungin
