ID 1 part 3

Question 1

gram positive antibiotics

Answer 1

vancomycin
lipoglycopeptides- tealvancin, oritavancin, dalbavancin
daptomycin
oxazolidiones - linezolid, tedizolid
quinupristin/dalfopristin

Question 2

vancomycin

Answer 2

moa- Dalanyl D alanyl
PO- c diff
MRSA
not VRE

Question 3

AE of vanc

Answer 3

otoxicity
nephrotoxic
red man syndrome

Question 4

lipoglycopeptiteds

Answer 4

tmoa- bacterial cell wall synthesis inhibitor-Dalanyl Dalanin,disrupts membrane potential
Telavancin
ortia
dalbavancin

Question 5

AE of lipoglycopeptides

Answer 5

teratogenic
same as vanc

Question 6

daptomycin

Answer 6

MRSA VRE
AE- falsly elevate P/INR
increase CPK
compatible with NS
inactivated in lungs by surfactants
risk with statins

Question 7

oxazolidiones

Answer 7

MOA- 50s ribosome synthesis blocker
linezolid
tedizolid

Question 8

linezolid

Answer 8

MAO inhibitor 2 week wash out period
myelosupression while under linezolid
decrease platelete hgb WBC
increase LFTs
IV:PO 1:1
no renal adjustment

Question 9

synercid

Answer 9

VRE
no renal adjustment
use with D5W

Question 10

other broad spectrum

Answer 10

tigecycline
polymyxim
chloramphenicol

Question 11

tigecycline

Answer 11

MOA- 30 s ribosome
kinda related to tetracycline
MRSA VRE
anerobes, atypicals
no activity against 3 Ps- pseudomonas protius providencia

Question 12

AE with tigecycline

Answer 12

risk of death
not for BBP
can increase INR

Question 13

polymyxim

Answer 13

nephrotoxic
neurotoxic
resiratory paralysis
used for MDR gram negatives - entero, klebsiella , pseudomonas

Question 14

clindamycin

Answer 14

lincoasamide 50s ribosomes
for MRSA
dont use in C diff

Question 15

metronidazole

Answer 15

do not use alcohol
anaerobe and protozaol function
bacterial vaginosis, trichomoniasis, cdiff
do not use in pregnancy 1st trimester
can cause metalic taste

Question 16

rifaximin

Answer 16

travellers diarrhea
IBS D
hepatic encephalopathy
not effective for systemic infections

Question 17

fidaxomicin

Answer 17

C diff

Question 18

fosfomycin

Answer 18

E coli
VRE
uncomplicated UTI

Question 19

nitrofurantoin

Answer 19

bacterial cell wall inhibitor
macrobid BID
GI upset
renail <60

Question 20

mupirocin

Answer 20

topical MRSA

Question 21

MMSA tx

Answer 21

nafcillin, oxacillin dicloxacillin
cefazolin cephalexin
amox.calvulanate, ampicillin
doxycycline, minocycline
SMX/TMP

Question 22

MRSA hospital

Answer 22

vanc
linezolid
daptomycin

Question 23

MRSA CA

Answer 23

SMX/TMP
doxy, mino
clinda
linezolid

Question 24

severe SSTIs MRSA and strep

Answer 24

vanc
linezolid
dapto
ceftaroline

Question 25

VRE

Answer 25

pen G linezolid dapto

Question 26

HPNEK

Answer 26

beta lactam SMX aminoglycosides cephalosporin other than 1st gen quinolones

Question 27

Atypical coverage

Answer 27

azithro, clarithro doxy quinolones

Question 28

pseudomonas

Answer 28

piperacillin cefepime ceftazidime/avi ceftolane/tazo carbapenems except erta cipro levo aztreo aminoglycosides polymyxim

Question 29

c diff

Answer 29

van fidaxomicin metronidazole

Question 30

B fragilis

Answer 30

metro beta lactam cefotetan carbapenems

Question 31

CRE

Answer 31

ceftazidime/avibactam polymyxim meropenem

Question 32

which abx doesnt reequire a renal dose

Answer 32

nafcicillin dicloxacillin ceftraiaxone clindamycin doxycycline macrolides matronidazole moxifloxacin linezolid

Question 33

which abx is taken without food

Answer 33

mostly taken with food except ampicillin oral suspension levofloxacin pen vk rifampin isoniazid itraconazole voriconazole

Question 34

which drugs are 1:1 ration IV to PO

Answer 34

levo linezolid metronidazole bactrim fluconazole posaconazole doxycycline, minocycline

Question 35

which drugs need light protextion

Answer 35

doxycycline micafungin