PK Flashcards
noyes whitney
rate of dissolution
fastest to slowest onset
IV>SL>ODT> IR> ER
what is a good bioavalilibility
> 70%
drugs with good bioavailibility
levofloxacin
linezolid
oral and IV dose same
absolute bioavalilibilty
F= 100 X AUC oral/AUC IV x dose IV /dose oral
dose of new dosage form
amount absorbed from current dosage/F of new dosage form
corrected calcium
calcium + 0.8(4-albumin)
phenytoin corrected
total phenytoin / (0.2 x albumin)+ 0.1
volume of distribution
amount of drug in body /conc of drug in lpasma
phase 1
oxidation
reduction
hydrolysis
phase 2
conjugation
glucuronidation
clearance
rate of elimination/drug conc
weka base elmination
acidify urine
weak acid elimination
alkaline urine
clearance formulae in th sheet
formuale sheet
zero order
constant amount of drug removed /time
300mg - 200- 100
1st order
most drugs
constant % removed /time
300-270-243
michaelis menten kinetics
voriconazole
phenytoin
theophylline
half of the maximal follows first order kinetics (lots of enzyme available)
the rate of metabolism approaches zero order
MMK increasing dose leads to
disproportionate increase in drug conc (no enzyme available or saturated
doubling dose can more than double the conc of drug
elimination rate constant
CL/VD
predicting drug conc
KE= (LNC1/C2)/t
half life
0.693/Ke
5 half lives = steady states
