PK

Question 1

noyes whitney

Answer 1

rate of dissolution

Question 2

fastest to slowest onset

Answer 2

IV>SL>ODT> IR> ER

Question 3

what is a good bioavalilibility

Answer 3

> 70%

Question 4

drugs with good bioavailibility

Answer 4

levofloxacin
linezolid
oral and IV dose same

Question 5

absolute bioavalilibilty

Answer 5

F= 100 X AUC oral/AUC IV x dose IV /dose oral

Question 6

dose of new dosage form

Answer 6

amount absorbed from current dosage/F of new dosage form

Question 7

corrected calcium

Answer 7

calcium + 0.8(4-albumin)

Question 8

phenytoin corrected

Answer 8

total phenytoin / (0.2 x albumin)+ 0.1

Question 9

volume of distribution

Answer 9

amount of drug in body /conc of drug in lpasma

Question 10

phase 1

Answer 10

oxidation
reduction
hydrolysis

Question 11

phase 2

Answer 11

conjugation
glucuronidation

Question 12

clearance

Answer 12

rate of elimination/drug conc

Question 13

weka base elmination

Answer 13

acidify urine

Question 14

weak acid elimination

Answer 14

alkaline urine

Question 15

clearance formulae in th sheet

Answer 15

formuale sheet

Question 16

zero order

Answer 16

constant amount of drug removed /time
300mg - 200- 100

Question 17

1st order

Answer 17

most drugs
constant % removed /time
300-270-243

Question 18

michaelis menten kinetics

Answer 18

voriconazole
phenytoin
theophylline
half of the maximal follows first order kinetics (lots of enzyme available)
the rate of metabolism approaches zero order

Question 19

MMK increasing dose leads to

Answer 19

disproportionate increase in drug conc (no enzyme available or saturated
doubling dose can more than double the conc of drug

Question 20

elimination rate constant

Answer 20

CL/VD

Question 21

predicting drug conc

Answer 21

KE= (LNC1/C2)/t

Question 22

half life

Answer 22

0.693/Ke

5 half lives = steady states