drug allergies and AE Flashcards
types of ADR
Type A= predictable
Type B= unpredictable
what type of ADR does a allergy fall under
Type B
drug intolerance is what type of ADR
B so is SJS or idiosyncratic reactions
what are the 4 types of allergic reaction
Type 1- IGe within 60 mins
type 2- 5-8 days
type 3- >1 week after drug expose
type 4- cell mediated or delayed SJS
BW
death or permanent disability
REMS
developed by manufaacturer approved by fda to ensure benefit>risk
Clozapine, Ipledge for isotretnoin
medication guides
patient handouts in non tecnical language
Naranjo scale used for
assessing ADR
>9 defenite
5-8 probable
1-4 possible
ADR reporting
FDA med watch (FAERS)
drugs that can cause photosensitivity
amiodarone
diuretics
MTX
quinolones
retinoids
st johns wort
sulfa abx
tacrolimus
tetracyclines
voriconazole
what drugs can cause thrombocytopenic purpura
P2Y12- clopid
sulfamethoxazole
what is a petechia
small lesion<3mm
what is ecchymoses
larger lesion >5mm
what should be avoided in SJS/TENS
systemic steroids
drugs that can case severe skin reactions
abacavir
allopurinol
carbamazepine
ehosuximide
lamotrigine
modafinil
nevirapine
penicillin
phenytoin
sulfamethoxazole
anaphylaxis tx
epi + diphen +steroid +IV fluids
epi is 1mg/mL
counseling for Epi
open blu cap injeck 90 degree
hold for 3 sec
massage the area for 10sec
penicillin allergy
avoid entire group
except acute otits media
not aztreonam
sulfa allergies
sulfamethoxazole
sulfasalazine
sulfadiazine
thiazide diuretics
loop diuretics except ethacrynic acid
celecoxib
**not for sulfate or sulfites just sulfonamides
drugs to avoid with penut allergy
clevidipine
propofol
progesterone
drugs to avoid with egg allergyb
cledipine
propofol
yellow fever vaccine
**flublok and flucelvax does not contain egg allergy
desensitized
pregnant with syphilis should be desensitized
- do not attempt in pt with SJS and TENS
