drug allergies and AE

Question 1

types of ADR

Answer 1

Type A= predictable
Type B= unpredictable

Question 2

what type of ADR does a allergy fall under

Answer 2

Type B

Question 3

drug intolerance is what type of ADR

Answer 3

B so is SJS or idiosyncratic reactions

Question 4

what are the 4 types of allergic reaction

Answer 4

Type 1- IGe within 60 mins
type 2- 5-8 days
type 3- >1 week after drug expose
type 4- cell mediated or delayed SJS

Question 5

BW

Answer 5

death or permanent disability

Question 6

REMS

Answer 6

developed by manufaacturer approved by fda to ensure benefit>risk
Clozapine, Ipledge for isotretnoin

Question 7

medication guides

Answer 7

patient handouts in non tecnical language

Question 8

Naranjo scale used for

Answer 8

assessing ADR
>9 defenite
5-8 probable
1-4 possible

Question 9

ADR reporting

Answer 9

FDA med watch (FAERS)

Question 10

drugs that can cause photosensitivity

Answer 10

amiodarone
diuretics
MTX
quinolones
retinoids
st johns wort
sulfa abx
tacrolimus
tetracyclines
voriconazole

Question 11

what drugs can cause thrombocytopenic purpura

Answer 11

P2Y12- clopid
sulfamethoxazole

Question 12

what is a petechia

Answer 12

small lesion<3mm

Question 13

what is ecchymoses

Answer 13

larger lesion >5mm

Question 14

what should be avoided in SJS/TENS

Answer 14

systemic steroids

Question 15

drugs that can case severe skin reactions

Answer 15

abacavir
allopurinol
carbamazepine
ehosuximide
lamotrigine
modafinil
nevirapine
penicillin
phenytoin
sulfamethoxazole

Question 16

anaphylaxis tx

Answer 16

epi + diphen +steroid +IV fluids
epi is 1mg/mL

Question 17

counseling for Epi

Answer 17

open blu cap injeck 90 degree
hold for 3 sec
massage the area for 10sec

Question 18

penicillin allergy

Answer 18

avoid entire group
except acute otits media
not aztreonam

Question 19

sulfa allergies

Answer 19

sulfamethoxazole
sulfasalazine
sulfadiazine
thiazide diuretics
loop diuretics except ethacrynic acid
celecoxib

**not for sulfate or sulfites just sulfonamides

Question 20

drugs to avoid with penut allergy

Answer 20

clevidipine
propofol
progesterone

Question 21

drugs to avoid with egg allergyb

Answer 21

cledipine
propofol
yellow fever vaccine

**flublok and flucelvax does not contain egg allergy

Question 22

desensitized

Answer 22

pregnant with syphilis should be desensitized
- do not attempt in pt with SJS and TENS