basic science

Question 1

What does the peripheral nervous system include

Answer 1

Somatic- muscles, voluntary

autonomic- GI and CV

Question 2

which is the primary neuro transmitter in the somatic nervous system

Answer 2

Acetylcholine binds to the nicotinic receptors in the muscles

Question 3

what is the two main divisions in the ANS

Answer 3

Sympathetic- fight or flight- epi/NE adrenergic receptors (a1a2b2)

Parasympathetic- rest and digest- ach- muscarinic receptors

Question 4

what NT binds to muscuranic

Answer 4

NT= ach

Question 5

what NT binds to nicotinic what drugs are agonist and antagonist

Answer 5

NT= ach

agonist= nicotine- HR and BP

antagonist= rocuronium

Question 6

what NT binds to alpha1

Answer 6

A1= peripheral smooth muscles

NT= E/NE- smooth muscle contraction and BP

Question 7

what NT binds to alpha 2

Answer 7

A2= brain, central

NT= E/NE- agonists block Eand NE decreases BP and HR

Question 8

what NT binds to Beta -1

Answer 8

B1= heart

NT= E/NE

Question 9

what NT binds to beta-2

Answer 9

B2= lungs

NT= E

Question 10

what NT binds to dopamine what drugs are agonist and antagonist

Answer 10

NT= dopamine

agonist- levadopa, pramipexole

antagonist- haloperidol, metoclopramide

Question 11

serotonin

Answer 11

NT= serotonin

Agonist= triptans

antagonist= ondansetron, quetiapine

Question 12

what does MAo do

Answer 12

breaks down dopamine–> NE–> epi–> excreted
serotonin –> excreted

Question 13

ach inhibitors and action

Answer 13

donepezil
rivastigme
galantamine
- to treat alzheimers or increase ACH

Question 14

ACE inhibitors and action

Answer 14

-prils
- decrease vasoconstrion which decrease BP for HPT, HF and AKI

Question 15

Catecholamine inhibitor and action

Answer 15

• entacapone
  decrease breakdown of dopa to tx parkinson

Question 16

COX inhibitors and action

Answer 16

NSAIDS to prevent inflamation

Question 17

MAO inhibitors and actions

Answer 17

phenelzine, tranylcypromine, isocarboxazid, selegline, rasagline , methyline blue and linezolid

• block MAO to stop breakdown of NTs and treats depression

Question 18

Phosphodiesterase inhibitors and action

Answer 18

sildenafil tadalafil

• preventing cGMP breakdown in smooth muscle to prolong muscle relaxation to treat ED

Question 19

vitamin K epoxide reductase inhibitor and action

Answer 19

• warfarin
  blocks to decrease clotting factor production

Question 20

xanthine oxidase inhibitors and action

Answer 20

allopurinol
decrease uric acid production and prevent gout

Question 21

what drugs are muscarinic receptor agonist

Answer 21

agonist= pilocarpine, bethanechol SLUDD

Question 22

what drugs are muscarinic receptor antagonist

Answer 22

antagonist= atropine, oxybutinin decrease SLUDD

Question 23

drugs that are A1 agonist

Answer 23

agonist=phenylephrine, dopa

Question 24

drugs that are A1 antagonist

Answer 24

antagonist= doxazosin, carvedilol, phentolamine

Question 25

drugs that are A2 agonist

Answer 25

agonist=clonidine, brimodine

Question 26

drugs that are A2 antagonist

Answer 26

antagonist= ergot alkaloids, yohimbine

Question 27

drugs that are B1 agonist

Answer 27

Agonist= dobutamine, isoproterenol, dopamine- increase CO, HR contractility

Question 28

drugs that are B1 antagonist

Answer 28

antagonist- BBs selective (metoprolol) and non selective (carvedilol and propranolol)

Question 29

drugs that are B2 agonist

Answer 29

agonists= albuterol, terbutaline, isoproterenol brochodilation

Question 30

drugs that are B2 antgonist

Answer 30

antagonist= non selective (prorpanolol, carvedilol)