basic science Flashcards
What does the peripheral nervous system include
Somatic- muscles, voluntary
autonomic- GI and CV
which is the primary neuro transmitter in the somatic nervous system
Acetylcholine binds to the nicotinic receptors in the muscles
what is the two main divisions in the ANS
Sympathetic- fight or flight- epi/NE adrenergic receptors (a1a2b2)
Parasympathetic- rest and digest- ach- muscarinic receptors
what NT binds to muscuranic
NT= ach
what NT binds to nicotinic what drugs are agonist and antagonist
NT= ach
agonist= nicotine- HR and BP
antagonist= rocuronium
what NT binds to alpha1
A1= peripheral smooth muscles
NT= E/NE- smooth muscle contraction and BP
what NT binds to alpha 2
A2= brain, central
NT= E/NE- agonists block Eand NE decreases BP and HR
what NT binds to Beta -1
B1= heart
NT= E/NE
what NT binds to beta-2
B2= lungs
NT= E
what NT binds to dopamine what drugs are agonist and antagonist
NT= dopamine
agonist- levadopa, pramipexole
antagonist- haloperidol, metoclopramide
serotonin
NT= serotonin
Agonist= triptans
antagonist= ondansetron, quetiapine
what does MAo do
breaks down dopamine–> NE–> epi–> excreted
serotonin –> excreted
ach inhibitors and action
donepezil
rivastigme
galantamine
- to treat alzheimers or increase ACH
ACE inhibitors and action
-prils
- decrease vasoconstrion which decrease BP for HPT, HF and AKI
Catecholamine inhibitor and action
- entacapone
decrease breakdown of dopa to tx parkinson
COX inhibitors and action
NSAIDS to prevent inflamation
MAO inhibitors and actions
phenelzine, tranylcypromine, isocarboxazid, selegline, rasagline , methyline blue and linezolid
- block MAO to stop breakdown of NTs and treats depression
Phosphodiesterase inhibitors and action
sildenafil tadalafil
- preventing cGMP breakdown in smooth muscle to prolong muscle relaxation to treat ED
vitamin K epoxide reductase inhibitor and action
- warfarin
blocks to decrease clotting factor production
xanthine oxidase inhibitors and action
allopurinol
decrease uric acid production and prevent gout
what drugs are muscarinic receptor agonist
agonist= pilocarpine, bethanechol SLUDD
what drugs are muscarinic receptor antagonist
antagonist= atropine, oxybutinin decrease SLUDD
drugs that are A1 agonist
agonist=phenylephrine, dopa
drugs that are A1 antagonist
antagonist= doxazosin, carvedilol, phentolamine
drugs that are A2 agonist
agonist=clonidine, brimodine
drugs that are A2 antagonist
antagonist= ergot alkaloids, yohimbine
drugs that are B1 agonist
Agonist= dobutamine, isoproterenol, dopamine- increase CO, HR contractility
drugs that are B1 antagonist
antagonist- BBs selective (metoprolol) and non selective (carvedilol and propranolol)
drugs that are B2 agonist
agonists= albuterol, terbutaline, isoproterenol brochodilation
drugs that are B2 antgonist
antagonist= non selective (prorpanolol, carvedilol)
