alzheimers Flashcards
sx of alzheimers
memory loss
repeating words
not able to learn
poor cordination and motor function
personality changes
inappropriate behavior
hallucinations
what drugs worsen dementia
antiemetics- promethazine
anti histamine - diphenhydramine and doxylamine
anti pscyh- chlorpromazine aripriprazole
barbituates-
benzos
central anticholinergics
peripheral anticholinergics
skeletal muscle relaxants– baclofen
opiods and sedatives
screening done by
MMSE<24
natrual products
vit e 2000units
ginko
*bleeding risk with both
vit D
drug tx
acetylcholinesterase inhibitor
with or without memantine
steps of therapy
dc any harmful drugs
exercise
eat healthy
BG control
activity of brain
start ach inhi
start memantine
what are some ach i
MOA- increase ach by blocking enzyme receptor
donepezil (aricet)
rivastigmine (Exelon)- patch
galantamine
MOA- blocks NMDA receptor inhibits glutamate
memantine (namenda)
drug interactions with ACHi
drugs that cause HR lowering
anticholinergics
caution with NSAIDS
common ACHi AE
nausea- take at night
diarrhea
decreased HR
exelon patch
apply new patch same time upper/lower back or upper arm
rotate sites (do not use same site upto14 days)
what are some AE of ACHi
N/Diar/ weight loss brady cardia
whcih are available ODT
donepezil
aricept
donepezil
namzeric
donepezil +memantine
namendaa
memantine