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naplex > ID 1 part 2 > Flashcards

ID 1 part 2 Flashcards

1
Q

B lactams

A

MOA cell wall synthesis inhibitor
penicillins
cephalosporin
carbapenems

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2
Q

penicillins

A

Gram + but no gram - or MRSA or atypical activity
antistap penicillin MSSA
amino penicillin HNPE
aminopenicillin + betalactamase - MSSA, HNPEK GN anerobes (fragilis)
extended spectrum penicillins + beta lactamase- MSSA, HNPEK, fragilis, CAPES P.arginosa

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3
Q

HNPEK

A

haemophilis
neiseira
proteus
e coli
klebsiella

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4
Q

CAPES

A

citro
acino
providenci
entero
serratia

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5
Q

natural penicillins

A

pen V potassium PO
Pen G (bicillin) IM

seizure
GI
SJS

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6
Q

anti staph MSMA penicillin

A

nnafcillin IV
oxacillin IV

** no renal dose adjustments

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7
Q

amino penicillin

A

amoxicillin
augmentin
ampicillin
unasyn

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8
Q

extended spectrum penicillins

A

piper/tazo zosyn

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9
Q

class effect of Penicillin

A

avoid in B lactam allergy
except in syphillis treatment during pregnancy and in HIV

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10
Q

which penicillin is for acute otitis media

A

amoxcillin

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11
Q

drug of choice for syphillis

A

PENG IM

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12
Q

which penicillin is only effective against pseudomonas

A

zosyn

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13
Q

cephalossporins

A

1st gen GP, PEK
2nd gen HNPEK
3rd gen HNPEK, pseudomonas
4th gen HNPEK, CAPES pseudomonas
5th gen MRSA, HNPEK

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14
Q

1st gen

A

cepfazolin
cephalexin (keflex)

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15
Q

2nd gen

A

cefuroxime
cefotetan

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16
Q

3rd gen

A

cefdinir
ceftriaxone
cefotaxime

Ceftazidime

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17
Q

4th gen

A

cefepime

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18
Q

5th gen

A

ceftaroline

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19
Q

cephalosporin combination

A

ceftazidime/avibactam
ceftolozane/tazobacatm

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20
Q

class effect

A

pen allergy
seizure risk

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21
Q

what are oral cefphalosporin

A

1st gen cephalexin
2nd gen cefuroxime
3rd gen cefdinir

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22
Q

what are IV cephalosporin

A

1st gen cefazolin
2nd gen cefotetan, cefoxitin
3rd gen ceftriaxone , cefotaxime , ceftazidime
4th gen cefepime
combination cephalosporin
5th gen ceftaroline

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23
Q

carbapenems

A

broad spectrum
covers all except MRSA VRE C diff
ertAPEnem no coverage for pseudomonaas , acino, enterococcus
do not use with penicillin allergy
seizure risk
IV only

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24
Q

mono bactam

A

aztreonam azatam

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25
Q

which is the only penicillin group that covers MRSA

A

5th gen cephalospoin ceftaroline

26
Q

which penicillin covers atypical

A

none

27
Q

which penicillin covers pseudomonas

A

carbapenem except ertapenem
3rd 4th gen
cetaroline cant
zosyn can

28
Q

aminoglycoside

A

conc depednant
renal damage
otoxicity
TBW for underweight
adj for obese

genta
tobra
amikacin

29
Q

gentamicin and tobramicin peak and troguh

A

5-10
<2

30
Q

amikacin peak and trough

A

20
<5

31
Q

hartford nomogram

A

extended interval dosing
7mg/kg random level after 10 hours

32
Q

quinolones

A

moa- DNA topoisomerase and DNA gyrase inhibitor
conc dependant
QT prolongation
tendonitis
peripheral neuropathy
CNS effect seizures
pneumonia, uti GI infections and travellers diarrhea

33
Q

what are some quinolones

A

levo
cipro
moxi
dela
ofloxacin

34
Q

cipro can be put throguh NG tube

A

FALSE

35
Q

Moxi can be used for UTI

A

NOPE

36
Q

AE of Quinolones

A

photosensitivty
tendinitis
peripheral neuropathy

37
Q

what are some IV quinolones

A

moxi
levo
cipro
dela

38
Q

which quinolone has activity against MRSA

A

delafloxacin

39
Q

which quinolone can be used for pseudomonas

A

cipro and levo

40
Q

which quinolones are eye drops

A

cipro
moxi
ofloxacin

41
Q

what are some drug interaction of quinolone

A

antacid
polyvalent cations
lanthanum carbonate
hypokalemia
hypo magnesimia

42
Q

which quinolone can increase caffeine , theophyllin and tizanidine

A

ciproflox

43
Q

which quinolone is not renally adjusted

A

moxifloxacin

44
Q

IV ratio levo and moxi to PO

A

1:1

45
Q

macrolides

A

moa- 50s ribosme inhibiting RNA protein synthesis
azithro
clarithro
erythro

excellent atypical coverage

46
Q

what are atypicals

A

legionella
chlymydia
mycoplasma
mycobacterium
haemophilus
gonorrhea

47
Q

AE for macrolides

A

QT prolongation
hepatoxic
GI upset

48
Q

clarithro and erythro should not be used with which drugs

A

statins

49
Q

which macrolide used for gasteroporosis

A

erythromycin

50
Q

which macrolide for chlymia mono and gonorrhea combination

A

azithromycin

51
Q

which macrolide for Hpylor

A

clarithromycin

52
Q

tetracyclines

A

moa - 30 s ribosome binding and inhibiting
atypicals and uniqu pathogens

doxycycline
minocycline
tetracycline

53
Q

what are unique pathogens

A

ricettsiae
bacillus anthracis
treponema pallidum

54
Q

what tetra cycline can be used in MRSA VRE and tick borne

A

doxycycline

55
Q

which tetracycline preferred for acne

A

minocycline

56
Q

which tetracycline does not require renal adjustment

A

doxycycline

57
Q

what is the IV to PO ratio for doxycycline and minocycline

A

1:1

58
Q

which tetracycline can cause DILE

A

minocycline

59
Q

what are some AE of tetracycline

A

antacids
lanthanum carbonate
cyp3a4 inhibitors
photosensitivity
children <8 pregnancy and breast feeding

60
Q

sulfonamides

A

moa- inhibition of folic acid
sulfamethoxazole/trimethoprim

other than HPNEK it also covers shigella salmonella stenotrophomonas
also opportunistic bacterias pneumocystis and toxoplasmosis

no coverage on pseudomonas, enterococcus, atypicals or anerobes

61
Q

AE of sulphonamides

A

sulfa allergy
skin reactions
G6PD defeciency
photosensitivity

naplex (78 decks)

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