ID 1 part 2 Flashcards
B lactams
MOA cell wall synthesis inhibitor
penicillins
cephalosporin
carbapenems
penicillins
Gram + but no gram - or MRSA or atypical activity
antistap penicillin MSSA
amino penicillin HNPE
aminopenicillin + betalactamase - MSSA, HNPEK GN anerobes (fragilis)
extended spectrum penicillins + beta lactamase- MSSA, HNPEK, fragilis, CAPES P.arginosa
HNPEK
haemophilis
neiseira
proteus
e coli
klebsiella
CAPES
citro
acino
providenci
entero
serratia
natural penicillins
pen V potassium PO
Pen G (bicillin) IM
seizure
GI
SJS
anti staph MSMA penicillin
nnafcillin IV
oxacillin IV
** no renal dose adjustments
amino penicillin
amoxicillin
augmentin
ampicillin
unasyn
extended spectrum penicillins
piper/tazo zosyn
class effect of Penicillin
avoid in B lactam allergy
except in syphillis treatment during pregnancy and in HIV
which penicillin is for acute otitis media
amoxcillin
drug of choice for syphillis
PENG IM
which penicillin is only effective against pseudomonas
zosyn
cephalossporins
1st gen GP, PEK
2nd gen HNPEK
3rd gen HNPEK, pseudomonas
4th gen HNPEK, CAPES pseudomonas
5th gen MRSA, HNPEK
1st gen
cepfazolin
cephalexin (keflex)
2nd gen
cefuroxime
cefotetan
3rd gen
cefdinir
ceftriaxone
cefotaxime
Ceftazidime
4th gen
cefepime
5th gen
ceftaroline
cephalosporin combination
ceftazidime/avibactam
ceftolozane/tazobacatm
class effect
pen allergy
seizure risk
what are oral cefphalosporin
1st gen cephalexin
2nd gen cefuroxime
3rd gen cefdinir
what are IV cephalosporin
1st gen cefazolin
2nd gen cefotetan, cefoxitin
3rd gen ceftriaxone , cefotaxime , ceftazidime
4th gen cefepime
combination cephalosporin
5th gen ceftaroline
carbapenems
broad spectrum
covers all except MRSA VRE C diff
ertAPEnem no coverage for pseudomonaas , acino, enterococcus
do not use with penicillin allergy
seizure risk
IV only
mono bactam
aztreonam azatam
which is the only penicillin group that covers MRSA
5th gen cephalospoin ceftaroline
which penicillin covers atypical
none
which penicillin covers pseudomonas
carbapenem except ertapenem
3rd 4th gen
cetaroline cant
zosyn can
aminoglycoside
conc depednant
renal damage
otoxicity
TBW for underweight
adj for obese
genta
tobra
amikacin
gentamicin and tobramicin peak and troguh
5-10
<2
amikacin peak and trough
20
<5
hartford nomogram
extended interval dosing
7mg/kg random level after 10 hours
quinolones
moa- DNA topoisomerase and DNA gyrase inhibitor
conc dependant
QT prolongation
tendonitis
peripheral neuropathy
CNS effect seizures
pneumonia, uti GI infections and travellers diarrhea
what are some quinolones
levo
cipro
moxi
dela
ofloxacin
cipro can be put throguh NG tube
FALSE
Moxi can be used for UTI
NOPE
AE of Quinolones
photosensitivty
tendinitis
peripheral neuropathy
what are some IV quinolones
moxi
levo
cipro
dela
which quinolone has activity against MRSA
delafloxacin
which quinolone can be used for pseudomonas
cipro and levo
which quinolones are eye drops
cipro
moxi
ofloxacin
what are some drug interaction of quinolone
antacid
polyvalent cations
lanthanum carbonate
hypokalemia
hypo magnesimia
which quinolone can increase caffeine , theophyllin and tizanidine
ciproflox
which quinolone is not renally adjusted
moxifloxacin
IV ratio levo and moxi to PO
1:1
macrolides
moa- 50s ribosme inhibiting RNA protein synthesis
azithro
clarithro
erythro
excellent atypical coverage
what are atypicals
legionella
chlymydia
mycoplasma
mycobacterium
haemophilus
gonorrhea
AE for macrolides
QT prolongation
hepatoxic
GI upset
clarithro and erythro should not be used with which drugs
statins
which macrolide used for gasteroporosis
erythromycin
which macrolide for chlymia mono and gonorrhea combination
azithromycin
which macrolide for Hpylor
clarithromycin
tetracyclines
moa - 30 s ribosome binding and inhibiting
atypicals and uniqu pathogens
doxycycline
minocycline
tetracycline
what are unique pathogens
ricettsiae
bacillus anthracis
treponema pallidum
what tetra cycline can be used in MRSA VRE and tick borne
doxycycline
which tetracycline preferred for acne
minocycline
which tetracycline does not require renal adjustment
doxycycline
what is the IV to PO ratio for doxycycline and minocycline
1:1
which tetracycline can cause DILE
minocycline
what are some AE of tetracycline
antacids
lanthanum carbonate
cyp3a4 inhibitors
photosensitivity
children <8 pregnancy and breast feeding
sulfonamides
moa- inhibition of folic acid
sulfamethoxazole/trimethoprim
other than HPNEK it also covers shigella salmonella stenotrophomonas
also opportunistic bacterias pneumocystis and toxoplasmosis
no coverage on pseudomonas, enterococcus, atypicals or anerobes
AE of sulphonamides
sulfa allergy
skin reactions
G6PD defeciency
photosensitivity
