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naplex > anemia > Flashcards

anemia Flashcards

1
Q

what type of Anemia is low MCV

A

microlytic <80 iron defeciency

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2
Q

what type of anemia is high MCV

A

B12 and Folic acid >100

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3
Q

how much elemental iron is in gluconate

A

12%

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4
Q

how much elemental iron is in sulfate

A

20%

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5
Q

how much elemental iron is in fumarate

A

33%

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6
Q

which iron has most to least

A

Carbonyl/poly/ferric maltol > fumarate>sulfate> gluconate

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7
Q

what is the recommended iron dose per day

A

100-200 mg taken on empty stomach avoiding H2Ras and PPIs

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8
Q

what is the antidote for Iron overdose

A

desferal deferoxamine

AE of iron can be constipation dark stools

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9
Q

what are the oral drug interactions associated with iron

A

antacids
quinolones and tetracyclines
bisphosphonates
levothyroxine

vit C increases absorption

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10
Q

IV iron use

A

most commonly on CKD with hemodialysis
CKD with ESA
unable to tolerate oral

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11
Q

what are some IV iron

A

Iron sucrose Venofer
ferumoxytol feraheme
dextran requires a test dose

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12
Q

what are the cause of B12 and folic acid defeciency

A

lack of intrinsic factor for B12
alcoholism
nutritional
GI disorders PPI use
metformin

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13
Q

B12 doseage

A

IM 100-1000mcg qdaily or weekly or monthly
cyanocobalamin

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14
Q

folic acid doasge

A

0.4-1mg daily

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15
Q

Aplastic anemia occurs when

A

Bone marrow fails to make enough RBC

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16
Q

Hemolytic anemia occurs when

A

drug induced or
sickle cell, G6PD deficiency

17
Q

what drugs can cause hemolytic anemia 15

A

cephalosporin
penicillin
quinidine
quinine
rifampin
isoniazid
levadopa
methyldopa

methylene blue *
nitrofurantoin *
sulfonamaide *
dapsone*
rasburicase *
pegloticase *
primaquine *
* AVOID IN G6PD

18
Q

what is nomocytic anemia

A

EPO defeciency
usually from CKD

19
Q

B12 defeciency can cause

A

neurological symptoms

20
Q

epogen MOA

A

stimulates BM to increase RBC production

21
Q

ESA AE

A

increased risk of death, stroke, VTE, thrombosis
arthralgia
can cause hypertension
increase risk of tumor progression

do not shake, refrigerate avoid light

22
Q

oral iron

A

take on empty stomach
causes constimation
dark stools

naplex (78 decks)

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