anemia Flashcards
what type of Anemia is low MCV
microlytic <80 iron defeciency
what type of anemia is high MCV
B12 and Folic acid >100
how much elemental iron is in gluconate
12%
how much elemental iron is in sulfate
20%
how much elemental iron is in fumarate
33%
which iron has most to least
Carbonyl/poly/ferric maltol > fumarate>sulfate> gluconate
what is the recommended iron dose per day
100-200 mg taken on empty stomach avoiding H2Ras and PPIs
what is the antidote for Iron overdose
desferal deferoxamine
AE of iron can be constipation dark stools
what are the oral drug interactions associated with iron
antacids
quinolones and tetracyclines
bisphosphonates
levothyroxine
vit C increases absorption
IV iron use
most commonly on CKD with hemodialysis
CKD with ESA
unable to tolerate oral
what are some IV iron
Iron sucrose Venofer
ferumoxytol feraheme
dextran requires a test dose
what are the cause of B12 and folic acid defeciency
lack of intrinsic factor for B12
alcoholism
nutritional
GI disorders PPI use
metformin
B12 doseage
IM 100-1000mcg qdaily or weekly or monthly
cyanocobalamin
folic acid doasge
0.4-1mg daily
Aplastic anemia occurs when
Bone marrow fails to make enough RBC
Hemolytic anemia occurs when
drug induced or
sickle cell, G6PD deficiency
what drugs can cause hemolytic anemia 15
cephalosporin
penicillin
quinidine
quinine
rifampin
isoniazid
levadopa
methyldopa
methylene blue *
nitrofurantoin *
sulfonamaide *
dapsone*
rasburicase *
pegloticase *
primaquine *
* AVOID IN G6PD
what is nomocytic anemia
EPO defeciency
usually from CKD
B12 defeciency can cause
neurological symptoms
epogen MOA
stimulates BM to increase RBC production
ESA AE
increased risk of death, stroke, VTE, thrombosis
arthralgia
can cause hypertension
increase risk of tumor progression
do not shake, refrigerate avoid light
oral iron
take on empty stomach
causes constimation
dark stools
