IBS Flashcards
IBS
inflammatory bowel syndrome
IBD vs IBS
IBS does not cause inflammation
UC
rectum and colon
chrons disease
any part
CD vs UC
UC bloody diarrhea
uncommon fistulas
colon as “COLITIS”
superficial
continuous pattern
smoking helps UC
CD blood or non bloddy diarrhea
common fistulas
entire GI
transmural
non continuos appearance
smoking is harmful
diagnosis for IBD
colonoscopy with tissu biopsy
drug tx for IBD
short courses of oral or IV steroids tapered over 8-12 weeks
tx in UC
mesalamine or 5-asa +- steroids
anti tnf
ustekinumab (stelara)
tofacitinib (xeljanz)
vedolizumab (entyvio
IV cyclsporine
tx in CD
steroids (+/- thiopurine or mtx
anti TNF +- thiopurine
ustekinumab
maintenence of UC
for mild
- mesalamine
moderate/severe
- anti tnf agents humira ,remicade, simponi
- thiopurine (azathioprine , mercaptapurine
-cyclospoirine
-IL receptor antagonist (ustekinumab or stelara
-janus kinase inhibitor - tofacitinib or xeljianz )
refractory
integrin receptor antagonist - vedolizumab
maintenence for CD
mild
oral budesonide
moderate- severe
anti TNF agents - humira , remicade, cimzia
- thiopurine (azathioprine, mercaptapurine )
-MTX
- Il receptro antagonist - ustekinumab or stelara
refractory
-integrin receptor antagonists- vedolizumab (entyvio), natalizumab (tysabri)
what are some steroids used in tx
prednisone (deltasone
budesonide (entocort- CD
uceris - UC
what are some short term AE of steroids
increase in apetite wieght gain
emotional instability
insomnia
indigestion
what are some long term AE of steroids
cushings
BP increase
increase in bg
cataratchs
osteoporosis
rectal steroids are indicated for which IBD
UC
hydrocortisone
budesonide uceris
