lab values and monitoring Flashcards by Nafi Dewan

average lifespan of RBC?
average lifespan of plt

120days
7-10 days

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BMP consists of

Electrolytes,
glucose,
renal function,
HCO3 or
bicarbs

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Comprehensive metabolic panel

BMP + albumin, ALT, AST, Total bilirubin and protein

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leukocytosis

increase in WBC

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polycythemia

Increase in RBC

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thrombocytosis

increase in PLT

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myelosuppression

decrease in WBC RBC abd PLT

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agranulocytosis

Decrease in WBCs that have granules neutrophilsm basophils and eosinophils

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Calcium range and what meds alters it

8.5- 10.5
if albumin low check corrected CA
increases due to supplemetns vit D and THiazide diuretics
decreases due to long term heparin use, loop, bisphos, cincalcet, calcitonin, foscarnet and topiramate

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1.3-2.1
increases due to antacids and laxatives with renal impairment
decreases due to PPI, diuretics, ampb, foscarnet, echinocandins, diarrhea , alcohol

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phosphate

2.3-4.7
increases in renal failure
decreases due to phosphate bincers, foscarnet, oral ca intake

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Potassium

3.5-5
increases due to ACE, ARBS, ARNI, canagliflozin, cyclospoine, tacrolimus, K supplements, bactrim drospirenone containing oral contraceptives, NSAIDs
decreases due to beta 2 agonists, diuretics, insulin, steroids

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135-145
increases due to hypertonic saline
decrease due to carbamazepine, oxcarbazepine, SSRI, diuretics

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Bicarbs

24-30 venous
increases due to loop, steroids
decreases due t topiramate, zonisamide, ASA overdose

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BUN

7-20
increases due to renal impairment and dehydration

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SCR

0.6-1.3
increases due to aminoglycosides, amph B, cisplatin, colistimethate, cyclosporine, loop. polymyxin, NSAIDS, dye, tacrolimus, vanc
decreases due to low muscle mass, amputation, hemodilution

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anion gap

5-12
increases suggest acidosis

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WBC

4-11x10^3
increases due to sytematic steroids
decreases due to clozapine, chemo, immunosupressants, vanc carbamazepine, cephalosporin

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RBC

males- 4.5-5.5 X10^6
females 4.1-4.9 X10^6

increases with ESAs smoking
decreases due to chemo, anemias
scikle cell anemia

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HGB

males- 13.5-18
females- 12-16

increase due to ESA
decrease due to anemia and bleeding
** coombs test and G6PD drug indduced anemias

MCV

80-100
increase is due to B12 or folate deficiency
decrease is due to iron deficiency

folic acid

5-25
decreases due to phenytoin, alcohol, prenatal, phenobarbital, mtx, bactrim

vit B-12

> 200pg/ml
decrease due to PPI, metformin, colchicine, chloramphenicol

Coombs test

needs to be negative if positive due to drugs:
penicillin, cephalosporin, methyldopa, methylene blue, quinidine, rasburicase, rifampin, sulfonamides

G6PD

5-14 - decrease is due to dapsone, methtylene blue, nitrofurantoin, pegloticase, rasburicase, sulfonamaides

anti factor XA activity

1-2 obtained 4 hours after LMWH increase due to heparin, LMWH, fondapari monitor in pregnancy obesity, low body weight, renal insufficiency

PT/INR

PT 10-13 s and varies INR <1.2 for not on warfarin increase is due to warfarin or liver disease false increase from daptomycin, oritavancin, telavancin

PLT

150-450 <20k high bleeding risk decrease due to heparin LMWH, fonda, linezolid, valporic acid Bone marrow chemo drugs

albumin

3.5- 5 decreases due to cirhosis and malnutrition drugs affected- warfarin, calcium, phenytoin

BILI

0.1-1.2

amylase and lipase

60-180 and 5-160 icnrease in pancreatitis- GLP DPP4 valporic and hypertriglycerdemia

Creatine kinase or CPK

assess inflamation of muscle muscle damage due to- dapto, statin, tenofovirm raltegravir, dolutegravir

troponin BNP NT pro BNP

0-0.1 <100 <61 Males 12-151 females diagnosis of MI BNP and NT BNP are for cardiac stress higher values for HF

thyroid tsh

0.3-3 Increase of TSH hypothyroidism - amiodarone interferons, lithium, Tyrosine kinase inhibitors and carbamazepine decrease of TSH hyperthyroidism - amiodarone interferons

URIC acid

increase due to diuretics, niacin, low dose aspirin, cyclosporin, tacrolimus, chemotherapy

g6pd defeciency and primaquine

increase destruction of rbc

what drugs should not be taken for people with G6PD defeciency

methylene blue dapsone pegloticase

CRP, RF, ESR, ANA

inflamation auto immune disorders DILE

What meds can cause DILE

hydralazine isoniazid methimazole methyldopa minocycline procainamide PTU quinidine termbinafine

carbamazepine TI

4-12

digoxin

0.8-2 afib 0.5-0.9 HF

gentamycin

<2 trough lithium

lithium

0.6-1.2

phenytoin

10-20 free = 1-2.5

theophyllune

5-15

valporic acid

50-100

what long term use med can cause B12 def

PPI metformin colchicine chloramphenicol

aptt goal

1.5-2 times more than hospirtal goal

steady state

5 doses