lab values and monitoring Flashcards
average lifespan of RBC?
average lifespan of plt
120days
7-10 days
BMP consists of
Electrolytes,
glucose,
renal function,
HCO3 or
bicarbs
Comprehensive metabolic panel
BMP + albumin, ALT, AST, Total bilirubin and protein
leukocytosis
increase in WBC
polycythemia
Increase in RBC
thrombocytosis
increase in PLT
myelosuppression
decrease in WBC RBC abd PLT
agranulocytosis
Decrease in WBCs that have granules neutrophilsm basophils and eosinophils
Calcium range and what meds alters it
8.5- 10.5
if albumin low check corrected CA
increases due to supplemetns vit D and THiazide diuretics
decreases due to long term heparin use, loop, bisphos, cincalcet, calcitonin, foscarnet and topiramate
MG
1.3-2.1
increases due to antacids and laxatives with renal impairment
decreases due to PPI, diuretics, ampb, foscarnet, echinocandins, diarrhea , alcohol
phosphate
2.3-4.7
increases in renal failure
decreases due to phosphate bincers, foscarnet, oral ca intake
Potassium
3.5-5
increases due to ACE, ARBS, ARNI, canagliflozin, cyclospoine, tacrolimus, K supplements, bactrim drospirenone containing oral contraceptives, NSAIDs
decreases due to beta 2 agonists, diuretics, insulin, steroids
NA
135-145
increases due to hypertonic saline
decrease due to carbamazepine, oxcarbazepine, SSRI, diuretics
Bicarbs
24-30 venous
increases due to loop, steroids
decreases due t topiramate, zonisamide, ASA overdose
BUN
7-20
increases due to renal impairment and dehydration
SCR
0.6-1.3
increases due to aminoglycosides, amph B, cisplatin, colistimethate, cyclosporine, loop. polymyxin, NSAIDS, dye, tacrolimus, vanc
decreases due to low muscle mass, amputation, hemodilution
anion gap
5-12
increases suggest acidosis
WBC
4-11x10^3
increases due to sytematic steroids
decreases due to clozapine, chemo, immunosupressants, vanc carbamazepine, cephalosporin
RBC
males- 4.5-5.5 X10^6
females 4.1-4.9 X10^6
increases with ESAs smoking
decreases due to chemo, anemias
scikle cell anemia
HGB
males- 13.5-18
females- 12-16
increase due to ESA
decrease due to anemia and bleeding
** coombs test and G6PD drug indduced anemias
MCV
80-100
increase is due to B12 or folate deficiency
decrease is due to iron deficiency
folic acid
5-25
decreases due to phenytoin, alcohol, prenatal, phenobarbital, mtx, bactrim
vit B-12
> 200pg/ml
decrease due to PPI, metformin, colchicine, chloramphenicol
Coombs test
needs to be negative if positive due to drugs:
penicillin, cephalosporin, methyldopa, methylene blue, quinidine, rasburicase, rifampin, sulfonamides
G6PD
5-14
- decrease is due to dapsone, methtylene blue, nitrofurantoin, pegloticase, rasburicase, sulfonamaides
anti factor XA activity
1-2 obtained 4 hours after LMWH
increase due to heparin, LMWH, fondapari
monitor in pregnancy obesity, low body weight, renal insufficiency
PT/INR
PT 10-13 s and varies
INR <1.2 for not on warfarin
increase is due to warfarin or liver disease
false increase from daptomycin, oritavancin, telavancin
PLT
150-450
<20k high bleeding risk
decrease due to heparin LMWH, fonda, linezolid, valporic acid Bone marrow chemo drugs
albumin
3.5- 5
decreases due to cirhosis and malnutrition
drugs affected- warfarin, calcium, phenytoin
BILI
0.1-1.2
amylase and lipase
60-180 and 5-160
icnrease in pancreatitis- GLP DPP4 valporic and hypertriglycerdemia
Creatine kinase or CPK
assess inflamation of muscle muscle damage due to- dapto, statin, tenofovirm raltegravir, dolutegravir
troponin
BNP
NT pro BNP
0-0.1
<100
<61 Males
12-151 females
diagnosis of MI
BNP and NT BNP are for cardiac stress
higher values for HF
thyroid
tsh
0.3-3
Increase of TSH hypothyroidism - amiodarone interferons, lithium, Tyrosine kinase inhibitors and carbamazepine
decrease of TSH hyperthyroidism - amiodarone interferons
URIC acid
increase due to diuretics, niacin, low dose aspirin, cyclosporin, tacrolimus, chemotherapy
g6pd defeciency and primaquine
increase destruction of rbc
what drugs should not be taken for people with G6PD defeciency
methylene blue
dapsone
pegloticase
CRP, RF, ESR, ANA
inflamation auto immune disorders
DILE
What meds can cause DILE
hydralazine
isoniazid
methimazole
methyldopa
minocycline
procainamide
PTU
quinidine
termbinafine
carbamazepine TI
4-12
digoxin
0.8-2 afib
0.5-0.9 HF
gentamycin
<2 trough
lithium
lithium
0.6-1.2
phenytoin
10-20
free = 1-2.5
theophyllune
5-15
valporic acid
50-100
what long term use med can cause B12 def
PPI
metformin
colchicine
chloramphenicol
aptt goal
1.5-2 times more than hospirtal goal
steady state
5 doses
