transplant Flashcards
induction immusupression
prevent acute rejection
IL2
antithymocyte globulin
simulect
basiliximab
maaintenence immunotherapy
Calcineurin inhibitor - tacrolimus
antiproliferative- mycophenolate
steroids
mycophenolate cellcept , myfortic DR
azathiprine
increase risk of infection
lymphoma
risk of abortions
diarrhea
gi upset
stable in D5W
decrease efficacy of oral contraceptives
calcineurin inhibitor
tacrolimus Prograf
cyclosporin gengraf
Mtor kinase
MOA- mtor kinase inhibitor
everolimus
sirolimus
CD80 86 binder
moa Tcell blocker
belatacept
* immunity to epstein barr
tx
basiliximab IL2 antagonist
antithymocyte globulin in higher risk patient
maintenct dose
CNis tacro or cyclosporine
adjuvants -mychophenolate, azathioprine, everolimus sirolimus, belatacept
steroids
warnings for transplant
infection risk
cancer risk
experienced prescribers should handle
signs of complications with tacrolimus and cyclosporine
nephrotoxic
diabetes
hypertension
signs of complication of mtor kinase
lipid parametes
tacrolimus is taken best with
empty stomach
every 12 hours
avoid grapefruit
gengraf/neoral ae
cyclosporine
HPT
nephropathy
hyperkalemia
hirutism
edema
BG
QT
over growth of gums
azathioprine has a DDI with
allopurinol
dose of aza needs to be reduced 75%
