ID:4 Flashcards
immunocompromised states
HIV or other with CD4 T lymp count<200
steroids>14 days at a dose of prednisone >20daily or 2mg/kg/day
asplenia as with sickle cell disaese following splectomy
immunosuppressants for autoimmune conditions
cancer therapy agents that destroy WBC ANC<500
common bugs for opportunistic prophylaxis
pneumocystis jiroveciipneumonia (PJP
toxoplasmosis gondii encepalitis
mycobacterium avium complex (MAC)
candida
PJP prophylaxis if CD4<200
DC if >200 for >3 months
-bactrim daily
if not bactrim 3X weekly
if still not
Dapsone
Dapsone +pyrimethamine (with leucovirin
atovaquone
toxoplasma gondii in CD4<100
bactrim daily
bactrim 3 times weekly
Dapsone +pyrimethamine (with leucovirin)
atovaquone
atovaquone +pyrimethamine (with leucovirin
MAC CD4<50 need to rule out MAC
if taking ART then DC
if not taking any ART
azithromycin 1200mg weekly
Azithro 600 twice weekly
clarithro 500 BID
is prophylaxis for
candidiasis
crypto meningitis
cytomegalovirus
MAC
PJP
TOX
candidiasis
fluconazole
itra/posa
is 2ndary prophylaxis recommended for candidaiss oral thrush
nope
crypto meningitis
amp B
fluconazole with flucytosine
2ndary prophylaxis for crypto meningitis
low dose fluconazole
MAC
clarithro /azithro
+ ethambutol
yes on 2ndary prophylaxis
PJP
bactrim high dose daily for 21 days
atovaquone
pentamidine IV
clinda+ primaquine
dapsone
TOX
pyrimethamine Leuco + sulfadiazine
all bactrim
clinda +pyri+leuco
atovaquone
atovaquone +sulfadiazine
ato +pyr+leu
leucovirins job is to
decrease myelosupression by pyromethiamine
