ID: 3 Flashcards
molds
aspergillus species
zyomycetes
dimorphic fungi
hitoplasma
blastomyces
coccidiodes
amph B
moa- binds to ergosterol
lipid formulation is less toxicities
good for most yeasts
great for molds and dimorphic fungi
is amph B oral?
no just injections
what are some notes on amp B
needs premedication with acetaminophen and diphenhydramine
decreases K and MG
dose 1.5mg /kg /day
infusion related issues
flucytosine
moa - converts to flurouracil and competes with uracil
not used alone with amp b combination
for meningitis (cryptococcal) or candida ingection
azole
moa decrease ergosterol synthesis
inhibits CYP450
all increases LFTs , QT
hich azole requires renal dose change
fluconazole
which azole is hepatoxic
liver
which azole can cause heart failure
itraconazole
which causes visual changes
voriconazole
which azole is taken with food
posaconazole
IV raio for all azole
1:1
which candida is fluconazole resistance
Krusei and glabrata
which azole is used for dimorphic
itraconazole
blastomycosis and histoplasmosis
