ID: 3 Flashcards
molds
aspergillus species
zyomycetes
dimorphic fungi
hitoplasma
blastomyces
coccidiodes
amph B
moa- binds to ergosterol
lipid formulation is less toxicities
good for most yeasts
great for molds and dimorphic fungi
is amph B oral?
no just injections
what are some notes on amp B
needs premedication with acetaminophen and diphenhydramine
decreases K and MG
dose 1.5mg /kg /day
infusion related issues
flucytosine
moa - converts to flurouracil and competes with uracil
not used alone with amp b combination
for meningitis (cryptococcal) or candida ingection
azole
moa decrease ergosterol synthesis
inhibits CYP450
all increases LFTs , QT
hich azole requires renal dose change
fluconazole
which azole is hepatoxic
liver
which azole can cause heart failure
itraconazole
which causes visual changes
voriconazole
which azole is taken with food
posaconazole
IV raio for all azole
1:1
which candida is fluconazole resistance
Krusei and glabrata
which azole is used for dimorphic
itraconazole
blastomycosis and histoplasmosis
hich azole is treatment of choice for molds such as aspergillus
voriconazole
echino candins moa
inhibits synthesis of Beta 1,3 D glucan
effective for all candida + aspergillus
only available through injections
what are some echinocandins
caspofungin Cancidas
micafungin mycamine
Allergies
do not require renal dose changes
other antifungals
Nystatin for oral candidiasis
terbinafen (lamisil)
clotrimazole troche/topical and vaginal
miconazole buccal
neuraminidase inhibitors
oseltamivir (tamiflu) capsule suspensions
zamamivir
peramivir
oseltamivir
age >12 years
75mg BID for 5 days tx and 10 days prophylactic
neuropsychiatric event s
endonuclease inhibitors
baloxavir marboxil
1 dose >12 years
only FDA approved drug
remdesevir veklury increase LFTs
herpes
HSV1 - oropharyngeal
HSV2 - genital
varicella zoster
cytomegalovirus
epstein barr virus
antivirals for HSV and varicella zoster
acyclovir (zovirax)
valacyclovir (valtrex)
famcyclovir
warnings of antivirals
based on IBWrenal impairment
cold sores herpes labialis
topical treatment
docosanol (Abreva)
acyclovir (zovirax)
penciclovir (denavir
acyclovir (systemic)
treatment of genital herpes
acyclovir
valacyclovir
famciclovir
herpes zoster treatment (shingles
acyclovir zovirax
valacyclovir (valtrex)
famciclovir
cytomegaloviru
ganicyclovir
valganciclovir
cidofovir
foscarnet
epsstein barr
amox/ampicillin
