benign prostatic hyperplasia Flashcards
what is the role of testosterone in growth
5alpha reductase metabolizes testosterone to dihydrotestosterone
what drugs can worsen BPH
anticholinergics= benztropine
anticholinergic effect drugs- antihistamine
decongestants
phenothiazines
caffiene
diuretics SNRIs
testosterone
adiagnosis of BPH
Digital rectal exam DRE
serum PSA- prostate specific antigen
sx of BPH
weak stream of urine
leaking of urine
bladder feels full
frequency of urine increases
bladder obstruction
natural products to treat BPH
saw palmetto
lycopene for cancer prevention
drug tx for BPH
alpha blockers alone or with alpha reductase inhibitors
PDE5 with or without alfa blocker
which alpha is for BPH
Alpha 1a
non selective alpha blocker have more side effects
true
cataracts and alpha blockers
alpha blockers should be delayed if cataracts
what are some non selective alpha 1 blocker
doxazosin (cardura)
terazosin
bedtime should not be used with CYP3A4 inhibitors
AE if high dose and with anti hypertensive or PDE5 inhibitos
IFIS in cataract surgery, abnormal ejaculation
selective alpha 1 a blockers
Tamsulosin (Flomax)
alfuzosin
silodosin
do not have to be taken nightly
alpha blocker shrink prostrate or change PSA levels
NOPE
which treatment for BPH reduces PSA levels and shrink prostrate
5 alpha reductase inhibitor
5 alpha reductase inhibitors
Finasteride (proscar)
Propecia
Dutasteride (Avodart)
AE for 5 a reductase
teratogenic
decrease libido cause breast enlargement
takes time to work
