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naplex > HIV > Flashcards

HIV Flashcards

1
Q

HIV

A

viral load increases and CD4 count decreases
CD4<200 AIDS

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2
Q

high risk

A

sexually active
hepatitis or tuberculosis

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3
Q

steps for diagnosis

A

HIV1 HIV2 antigen p24 antigen
2 weeks post infecition
if positive cofirmatory test with differentiation
if negative or intermediate nucleic acid test

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4
Q

otc test

A

should be measured 3 month post infection due to lag time

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5
Q

stage 1 of HIV

A

binding and attachment
CCR5
*ccr5 antagonist- maraviroc
attachment inhibitor fostemsavir
post attachmetn inhibitor ibalizumab

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6
Q

stage 2

A

fusion
fusion inhibitor- enfuvitide

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7
Q

stage 3

A

reverse transcription
NRTIs - emtricitabine, tenofovir
NNRTIs- efavirenz, rilpivirine

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8
Q

stage 4

A

inegration
INSTIs -bictegravir, dolutegravir, raltegravir

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9
Q

stage 5

A

replication
none

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10
Q

stage 7

A

budding and maturation
protease inhibitor- atazanavir, darunavir

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11
Q

one pill once daily

A

biktarvy
triumeq
dovato

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12
Q

two pills once daily

A

tivicay+truvada
tivicay +descovy
isentress +truvada
isentress+ descovy

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13
Q

which ones not to use in CRCL<30

A

bikatarvy
triumeq
dovato
truvada
descovy

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14
Q

ARTI regimens need atleast

A

2 NRTis and one base

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15
Q

NRTIs

A

abacavir
TDF
TAF
zidovudine

emtricitabine
lamivudine

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16
Q

all NRTIs

A

lactic acidosis
hepatomegaly
steatosis

17
Q

before starrting abaccavir

A

HLB 5701
risk of MI

18
Q

hyperpgmentation with which drug

A

emtricitabine

19
Q

TDF AE

A

renal impairment
decrease in bone density

20
Q

which drug can cause myopathy

A

zidovudine

21
Q

INSTIs

A

bictegravir
dolutegravir
elvitegravir
raltegravir

“tegravir”
BRED

22
Q

which INSTis can increase SCR

A

bictegravir dolutegravir

23
Q

which INSTI can cause myopathy and increase CPK

A

raltegravir, dolutegravir

24
Q

INSTIs AE

A

do not take with cations
ae includes HA weight gain diarrhea

25
Q

NNRTIs

A

efavirenz
rilpivirine

26
Q

AE of NNRTI

A

hepatoxic, SJS
psychiatric conditions

27
Q

do not use rilpivirine with

A

PPIs H2Ra antacids

28
Q

protease inhibitos

A

atazanavir
darunavir

:navir”

29
Q

all PI

A

major cyp3a4 substrats and inhibitors
Decrease HDL
increase TG
increase BG
abdominal adipose

30
Q

boosters

A

ritonavir
cobisistat

31
Q

drug interactions with boosters

A

tamsulosin, alfuzosin
colchicine
stain
azole antifungals
amiodarone
PDe5

32
Q

prep

A

do not have HIV but take 2 drug combination (truvada/descovy )
for prevention
confirm HIV negative
crcl>60 for truvada cr cl>30 for descovy
screen HepB and sti
provide no more than 90 days supply
follow up every 3 months

naplex (78 decks)

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