HIV Flashcards

1
Q

HIV

A

viral load increases and CD4 count decreases
CD4<200 AIDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

high risk

A

sexually active
hepatitis or tuberculosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

steps for diagnosis

A

HIV1 HIV2 antigen p24 antigen
2 weeks post infecition
if positive cofirmatory test with differentiation
if negative or intermediate nucleic acid test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

otc test

A

should be measured 3 month post infection due to lag time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

stage 1 of HIV

A

binding and attachment
CCR5
*ccr5 antagonist- maraviroc
attachment inhibitor fostemsavir
post attachmetn inhibitor ibalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

stage 2

A

fusion
fusion inhibitor- enfuvitide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

stage 3

A

reverse transcription
NRTIs - emtricitabine, tenofovir
NNRTIs- efavirenz, rilpivirine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

stage 4

A

inegration
INSTIs -bictegravir, dolutegravir, raltegravir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

stage 5

A

replication
none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

stage 7

A

budding and maturation
protease inhibitor- atazanavir, darunavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

one pill once daily

A

biktarvy
triumeq
dovato

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

two pills once daily

A

tivicay+truvada
tivicay +descovy
isentress +truvada
isentress+ descovy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

which ones not to use in CRCL<30

A

bikatarvy
triumeq
dovato
truvada
descovy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ARTI regimens need atleast

A

2 NRTis and one base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

NRTIs

A

abacavir
TDF
TAF
zidovudine

emtricitabine
lamivudine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

all NRTIs

A

lactic acidosis
hepatomegaly
steatosis

17
Q

before starrting abaccavir

A

HLB 5701
risk of MI

18
Q

hyperpgmentation with which drug

A

emtricitabine

19
Q

TDF AE

A

renal impairment
decrease in bone density

20
Q

which drug can cause myopathy

A

zidovudine

21
Q

INSTIs

A

bictegravir
dolutegravir
elvitegravir
raltegravir

“tegravir”
BRED

22
Q

which INSTis can increase SCR

A

bictegravir dolutegravir

23
Q

which INSTI can cause myopathy and increase CPK

A

raltegravir, dolutegravir

24
Q

INSTIs AE

A

do not take with cations
ae includes HA weight gain diarrhea

25
NNRTIs
efavirenz rilpivirine
26
AE of NNRTI
hepatoxic, SJS psychiatric conditions
27
do not use rilpivirine with
PPIs H2Ra antacids
28
protease inhibitos
atazanavir darunavir :navir"
29
all PI
major cyp3a4 substrats and inhibitors Decrease HDL increase TG increase BG abdominal adipose
30
boosters
ritonavir cobisistat
31
drug interactions with boosters
tamsulosin, alfuzosin colchicine stain azole antifungals amiodarone PDe5
32
prep
do not have HIV but take 2 drug combination (truvada/descovy ) for prevention confirm HIV negative crcl>60 for truvada cr cl>30 for descovy screen HepB and sti provide no more than 90 days supply follow up every 3 months