HIV Flashcards
HIV
viral load increases and CD4 count decreases
CD4<200 AIDS
high risk
sexually active
hepatitis or tuberculosis
steps for diagnosis
HIV1 HIV2 antigen p24 antigen
2 weeks post infecition
if positive cofirmatory test with differentiation
if negative or intermediate nucleic acid test
otc test
should be measured 3 month post infection due to lag time
stage 1 of HIV
binding and attachment
CCR5
*ccr5 antagonist- maraviroc
attachment inhibitor fostemsavir
post attachmetn inhibitor ibalizumab
stage 2
fusion
fusion inhibitor- enfuvitide
stage 3
reverse transcription
NRTIs - emtricitabine, tenofovir
NNRTIs- efavirenz, rilpivirine
stage 4
inegration
INSTIs -bictegravir, dolutegravir, raltegravir
stage 5
replication
none
stage 7
budding and maturation
protease inhibitor- atazanavir, darunavir
one pill once daily
biktarvy
triumeq
dovato
two pills once daily
tivicay+truvada
tivicay +descovy
isentress +truvada
isentress+ descovy
which ones not to use in CRCL<30
bikatarvy
triumeq
dovato
truvada
descovy
ARTI regimens need atleast
2 NRTis and one base
NRTIs
abacavir
TDF
TAF
zidovudine
emtricitabine
lamivudine
all NRTIs
lactic acidosis
hepatomegaly
steatosis
before starrting abaccavir
HLB 5701
risk of MI
hyperpgmentation with which drug
emtricitabine
TDF AE
renal impairment
decrease in bone density
which drug can cause myopathy
zidovudine
INSTIs
bictegravir
dolutegravir
elvitegravir
raltegravir
“tegravir”
BRED
which INSTis can increase SCR
bictegravir dolutegravir
which INSTI can cause myopathy and increase CPK
raltegravir, dolutegravir
INSTIs AE
do not take with cations
ae includes HA weight gain diarrhea
NNRTIs
efavirenz
rilpivirine
AE of NNRTI
hepatoxic, SJS
psychiatric conditions
do not use rilpivirine with
PPIs H2Ra antacids
protease inhibitos
atazanavir
darunavir
:navir”
all PI
major cyp3a4 substrats and inhibitors
Decrease HDL
increase TG
increase BG
abdominal adipose
boosters
ritonavir
cobisistat
drug interactions with boosters
tamsulosin, alfuzosin
colchicine
stain
azole antifungals
amiodarone
PDe5
prep
do not have HIV but take 2 drug combination (truvada/descovy )
for prevention
confirm HIV negative
crcl>60 for truvada cr cl>30 for descovy
screen HepB and sti
provide no more than 90 days supply
follow up every 3 months
