Systemic Vasculitis

Question 1

Vasculitic conditions are ?, should always be considered when a patient
presents with ? ? symptoms

vasculitic conditions can be primary, or secondary to ?, ? or CTDs (most commonly ?). They are classified according to the ? of vessel involved·

Answer 1

rare
multiple systemic
infection
malignancy
SLE
size

Question 2

Multiple system sx

General: ?, fever, weight loss, ?, arthralgia.
Skin: palpable ?, ?.
GI: mouth ?, abdominal pain and ?.
Respiratory: ?, dyspnoea.
ENT: epistaxis, ?.
Cardiac: chest ?.
Neuro: ?

Answer 2

malaise
myalgia
purpura
ulceration
ulcers
diarrhoea
haemoptysis
crusting
pain
neuropathies

Question 3

Medium Arteries;

Classic Polyarteritis ?: multi-systemic symptoms, multiple micro-? on ?.
? Disease: fever, ?, lymphadenopathy and ? erythema in
children, can affect ? arteries.

Answer 3

nodosa
aneurysms 
angiography
kawasaki
rash
palmar
coronary

Question 4

Medium Arteries/ Small Vessels (? positive);

? granulomatosis: commonly affects the ?, kidney and ???systems, with granuloma formation seen on ?

Churg-Strauss syndrome: associated with ? onset ?/?, and ?-? involvement.

Microscopic Polyangiitis: commonly causes pulmonary-renal syndrome
(? and ?).

Answer 4

anca
wegeners
lung
ent
biopsies
late
asthma/atopy
cardio-pulmonary
haemoptysis + haematuria

Question 5

Large Arteries;
? ? Arteritis: see above.
? arthritis: ? adults, present with ? limb claudication and
?.

Answer 5

Giant Cell
Takayasu's
young
upper
stroke

Question 6

Small Vessels (leucocytoclastic, usually confined to ?);
???: see renal.
Cryoglobulinaemia: associated with hepatitis ?, leads to rash, ? and ?

Answer 6

skin
HSP
C
neuropathy
arthralgia

Question 7

Bloods

FBC: ? in primary disease/ infection, leukopenia in ?s.
LFTs: ? is a common secondary cause of vasculitis.
? markers.
Immunology;
o c-ANCA associated with ?.
o ? associated with Churg-Strauss syndrome and microscopic polyangiitis.

Answer 7

leukocytosis
CTDs
hepatitis
inflam
wegeners
p-ANCA

Question 8

Bedside

? & Urine Dip: essential investigation, ? involvement often determines
prognosis. ? if abnormalities.

Further tests

Tissue ?: essential to confirm diagnosis (exclude infection) before treatment with potentially toxic ? (skin biopsy, or often
? biopsy if there are ? ? abnormalities).

Answer 8

bp
renal
microscopy
biopsy
immunosuppressants
renal
urine dip

Question 9

Management;

Depends on the ? of vessel involved.
? are the mainstay of treatment, with prolonged dose reduction over ? months.

Answer 9

size
corticosteroids
12

Question 10

Management

? (low dose or pulse) is often used in ANCA-positive disease to induce remission (but can lead to ?).

? is often used in Kawasaki disease.
? ? may be used in life-threatening conditions.

Answer 10

cyclophosphamide
infertility
IVIG
plasma exchange