Polymyositis + Dermatomyositis

Question 1

Polymyositis and dermatomyositis are rare conditions, associated with the ? phenotype

Both conditions can be associated with ???, ?? or systemic ?, and are
associated with various ?, so occult ? should always be
screened for.

Answer 1

HLA-B8/DR3
SLE
RA
sclerosis
malignancies
malig

Question 2

Polymyositis;
_ Inflammation of ? muscle causing ? muscle weakness.
o Generally causes weakness without ?
o There may be associated muscle ?.
o Onset can be ? or ?.
o It is associated with ?, weight loss and ?.
o The patient will have difficulty ? and climbing stairs.

If left untreated, ? muscle involvement can lead to ?
failure.

Answer 2

striated
proximal
pain
wasting
acute
insidious
malaise
fever
squatting
resp
resp

Question 3

Dermatomyositis;

Polymyositis with associated ? involvement.
o Classic ? rash (?discolouration).
o Associated ? oedema.
o ? patches over the ?(Gottron’s papules)

Answer 3

skin
heliotropic
purple
periorbital
vasculitic
knuckles

Question 4

Bloods;
Serum ?: ? reflecting muscle damage.
?: rarely raised (5%).
?: most are positive.
RF: ?% are RF positive.
Myositis specific antibodies.

Answer 4

CK
raised
ESR
ANA
50

Question 5

?;
EMG shows a characteristic pattern.

MRI;
To detect areas of abnormal ?.

? muscle biopsy;
Shows fibre ? with ? infiltrate.

Further investigations as appropriate to screen for ?.

Answer 5

electromyography
muscle
needle
necrosis
inflam
malignancy

Question 6

Management;
?/? until myositis is clinically inactive.
???? therapy may be used in some cases.

Answer 6

dmards
pred
IVIG

Question 7

Inclusion Body Myositis;
–Affects ? males over ?, with ? onset of proximal and distal muscle ?, which may be ?.
–? is less frequently positive, and myositis specific ? will not be positive.
–Muscle ? shows inflammatory infiltrate and vacuoles containing ?
(‘inclusion bodies’).
–It is ?, and rarely responds to ?/?
combinations.

Answer 7

white
50
insidious
wasting
asym
ana
antigens
biopsy
beta-amyloid
progressive
pred/dmard