SLE - Features

Question 1

Pathology;

SLE is a common, but frequently undiagnosed ? ? disorder.
It affects ? and middle aged ?, particularly of ? descent.
It is an ? condition, with ? directed at a range of
tissues, and the aetiology unknown.

Answer 1

conn tiss
young
women
asian
autoimmune
autoantibodies

Question 2

Skin involvement (75% of cases);

Chronic ? LE: red, ? plaque usually on the ?/?.

Malar rash: symmetrical, ? erythematous rash across the cheeks and bridge of nose (spares ? ?).

Photosensitivity reactions: ? in ?-exposed areas, in either ? or ? patterns.
? is also common.

Answer 2

discoid
scaly
face/scalp
raised
nasal cleft
rashes
sun
discoid
malar
alopecia

Question 3

Presentation is extremely ? due to the number of organ systems involved, but
? is often a predominant feature along various other symptoms;

20% will also have ? ? lesions, with superficial erosions and ?.

Answer 3

varied
fatigue
oral mucosal
ulcers

Question 4

CNS involvement (60% of cases);

Non-organic disorders most common, e.g. ? and ?.
Organic brain disorders such as ? ? ? seizures may also be the presentation.
? occlusion and ? can occur with associated ??? syndrome

Answer 4

depression
anxiety
grand mal epileptic
vascular
infarction
APL

Question 5

Renal involvement (30% of cases);

? disease that can follow many patterns, most commonly ? ?.

Heart involvement (25% of cases);

Most commonly ?, rarer lesions can occur such as ? valve lesions and cardiomyopathy.
SLE patients also at higher ?risk.

Answer 5

glomerular
interstitial nephritis
pericarditis
aortic
athersclerotic

Question 6

Haematological involvement;

Normocytic ? anaemia.
Thrombocytopenia: due to ? ?.
Leukopenia, most commonly due to ?.
Occasionally can be an autoimmune ? anaemia due to ? ? antibodies: positive ? test.

Answer 6

hypochromic
antiplatelet antibodies
lymphopenia
haemolytic
red cell
coombs

Question 7

MSK involvement

? (90%), usually beginning in the ?, ? and ?, often
misdiagnosed as ??.
? (50%).

Lung involvement (50% of cases);

Recurrent ? and pleural ?.
Pulmonary ?.

Answer 7

arthritis
wrist
knee
fingers
RA
myalgia

pleurisy
effusions
fibrosis