SLE - Ix + Mx

Question 1

Bloods;
FBC: ? hypochromic anaemia, ?-penia, ?-penia.
ESR/CRP: ESR ?, CRP ?.
U&Es: may be deranged if ? present.
Serum ???: almost always positive.
Serum ??: positive in 25%.

Answer 1

normocytic
thrombo
leuko
raised
normal (often)
glomerulonephritis
ANA
RF

Question 2

Bloods;
?-?: specific for SLE, but sensitivity of 50%.
??? antibodies (anti-Ro/ anti-La) often present.
Serum ? levels: C3/4 levels ? in active disease.
??? antibodies: many patients will have ? antibodies, representing comorbid ???.

Answer 2

anti-dsDNA
RNA
complement
reduced
APL
anticardiolipin
APL

Question 3

Urine ?/ BP;
To check for ? involvement.
Histology;
Characteristic histology/ ?seen in ?/? biopsies.

Answer 3

dip
renal
immunofluorescence
kidney/skin

Question 4

Management;

Avoid excessive ? and ?? risk factors.
Monitor for signs of ? and treat ?.
These patients should be regularly monitored in clinic for signs of ? disease;
0 ?/clinical examination.
o ???, ???, C?/?, urine ?.

Answer 4

sunlight
CV
infection
early
active
hx
U+E, FBC, 3/4, dip

Question 5

Mild disease;
o ? and ?.
• Combination therapy helps ? disease, ? and fatigue.
More severe disease (e.g. ?/? involvement);
o ?, with DMARDs such as ? for steroid sparing.

Answer 5

nsaids
hydroxychloroquine
skin
arthralgia
renal/cardiac
pred
azathioprine