Paget's Disease of Bone - Background

Question 1

PDB is a ? disease of ? origin affecting the bones in the ?, with excessive uncontrolled ? of bone by ? abnormal ? osteoclasts.
It is a disease of the ?, thought to affect up to 10% by age ?.
The destruction of ? and ? bone comes in ?, with each followed by an ? response, occurring in a haphazard fashion.

Answer 1

common
unknown
elderly
resorption
large
multinucleated
elderly
85
trabecular 
cortical
waves
osteoblastic

Question 2

Bone architecture becomes ?, and although there may be an increase
in bone ?, it is paradoxically ? than normal.
The new bone has a characteristic ?, non-lamellar pattern, with ?
of the ? spaces.

Answer 2

distorted
bulk
weaker
woven
fibrosis
marrow

Question 3

Clinical features;
-Up to ?% are asymptomatic, despite radiological evidence.

Symptoms;
? and ? bone pain.
o Bone deformities (? tibia/ ?changes).
o ? nerve palsies due to ?.
--> • Classically CN ?.
o ? failure due to increased bone ? flow.

Answer 3

80
waxing waning
bowed
skull
cranial
compression
8
cardiac
blood

Question 4

Bone pain, ? fractures and ? is the textbook presentation.
Diagnosis may follow an incidental finding on XR or LFTs (raised ?)
Pagetic bone has a 30x increased risk of developing osteogenic ?
(although the overall risk remains ?).

Answer 4

pathological
deafness
alp
sarcoma
small