Sjogren's syndrome

Question 1

Primary Sjogren’ s syndrome: ? eyes (? sicca) in the absence of any ? disease.

Secondary Sjogren’s syndrome: presence of ?symptoms in the presence of an ? disease.
—-> Most commonly ??, also ???, ? and poly?.

Sjogren’s is associated with the HLA-B?/DR? phenotype.

Answer 1

dry 
keratoconjunctivitis
AI
sicca
AI
RA
SLE
scleroderma
polymyositis
8/3

Question 2

Symptoms;

Dry ? and ?.
Salivary and ? gland ?.
? dryness.
Associated systemic features: ?-algia, ?’s, ? motility issues.

Answer 2

eyes
mouth
parotid
enlargement
vaginal
arthralgia
reynaud's
oesophageal

Question 3

Investigations;

? ? test;
o Specialised filter paper placed inside ? eyelid,

Answer 3

schirmer tear
lower
1
5
tear
raised
ana
ro
la

Question 4

Management;

Artificial ? and ?-replacement solutions.
Prognosis is ?, with ? and ? function normally stabilizing.
o Absolute prognosis is more related to that of the underlying disorder.
One in six patients will develop ? ?-cell lymphoma.

Answer 4

tears
saliva
good
lacrimal
salivary
non-hodgkins b cell lymphoma