MSK sepsis - pathology + radiography

Question 1

Osteomyelitis pathology

Inflammation: acute inflammatory response, leading to increased
? ? and intense ?.
Suppuration: pus appears in the ? (day 2) and forces its way to the ? to form a ? abscess, which can form a ? to drain to the surface, or drain into soft tissues/ ?.

Answer 1

intraosseous pressure
pain
medulla
surface
subperiosteal
sinus
joints

Question 2

Osteomyelitis pathology

Necrosis: compromised ? ?leads to necrosis by day ?.
? bone formation: ? stimulate ? bone formation.
Resolution: bone will eventually heal (although remain ?) with
? and ? intraosseous pressure

Answer 2

bl sup
7
new
osteoblasts
new
thickened
abx
controlled

Question 3

Osteomyelitis imaging

No abnormality on XR for ?days, but increased bone activity on ? scans.
By two weeks there may be ? bone density and ? bone formation.
Eventually there will be ? and thickening of the ?.

Answer 3

10
radioisotope
reduced
new
sclerosis
cortex

Question 4

Septic arthritis pathology

The joint is invaded by ? spread, by eruption of a bone ? or directly through a ? wound.
Infection spreads through the joint and ? is destroyed.

Answer 4

haematogenous
abscess
penetrating
cartilage

Question 5

Septic arthritis pathology

Pus bursts out of the joint to form ? and ?.
With healing, the raw ? surfaces may adhere to produce ?.

Answer 5

abscesses
sinuses
articular
ankylosis

Question 6

Septic arthritis imaging

? are of no value in the acute diagnosis of septic arthritis, but there are characteristic changes related to the disease pathophysiology;
Soft tissue ? in the first ? weeks, with ? of the joint space due to ?.
Later X-Rays will then show ? joint space as the ? is
destroyed, with signs of bone ? and finally ? if severe.

Answer 6

xrays
swelling
2
widening
effusion
narrowed
cartilage
destruction
ankylosis