Corticosteroid Use

Question 1

Act by inhibiting ? of COX-2, ?, and I Ls.
Also increase ?-1 production, which has anti-inflammatory effects.
Can be oral (?), but many rheumatology centres prefer ? (methylprednisolone) as this has a ? effect that self-tapers ?.

Answer 1

transcription
cytokines
annexin
pred
IM
depot
down

Question 2

There are widespread side effects;
o ?/poor ? healing.
o ? ulceration.
0 Acute ? insufficiency upon ? (thus tapered).
o ? syndrome (plethoric faces).
o Diabetes Mellitus.
o ? 
o ? necrosis.
o Psychological effects (?, ?).
o Inter-scapular fat pad: '? ?'.

Answer 2

infection
wound
peptic
adrenal
withdrawal
cushings
osteoporosis
avascular
depression, psychosis
buffalo hump

Question 3

long term steroids -> need co-prescribed ? protection (commonly with ?s), vitamin ? and ? for bone protection

Answer 3

gastro
ppi
d
osteoporosis

Question 4

Intra-articular injections;

• Can have a ? and ? effect.
  Do not repeat more than ?x in ? months.
  There can be ? absorption and side-effects.
  May be into ? or periarticular structures to give ? relief
  -The diagnostic use comes in that the preparation often contains ? ?, and so if the pain resolves within a ?period of time, we can
  be reasonably confident that the pain is coming from the structure injected.

Answer 4

Dx and Tx
3x
six
systemic
joints
pain
LA
short