Metastatic Bone Cancer + Multiple Myeloma Flashcards
Multiple Myeloma;
Presentation
Bone ? leads to ? fractures, particularly in the ?
leading to ?.
There will also be signs of ? ? infiltration and ? impairment, so the patient can also present with ??? signs, recurrent ?, signs of
?, hyper? etc.
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Multiple Myeloma
Investigation XR shows ? ? ? lesions. Management of bone pain; ? for local disease control. Spinal ? and ? if necessary.
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Bony Mets
Most common cause of ? bone disease in adults, with deposits most commonly found in the ? ?.
Presentation Unremitting, ? pain, worse in ? and may be sharp upon ? ?. Features of ?. ? fractures. ? symptoms.
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Bony Mets
On examination there will be bone ?, reduced ?
of the joints and local ?.
More rarely it can present as spinal cord ?, leading to
? pain and ? dysfunction.
The five most common tumours that metastasize to bone are ?, lung (?), ?, ? and ?
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Bony Mets
Differentials may be ? ?, ? or ?.
Investigation
Skeletal ? scans;
0 Show metastases as ‘?areas’ before radiological changes occur.
Skeletal XR;
0 ? or ? areas once the tumour reaches a certain size.
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Bony Mets
Ix
CT/MRI; 0 To define bone ?, ?involvement and tumour ?. 0 Imaging for the ? tumour. CT guided ?; 0 If the diagnosis is in doubt. General bloods+/- ? ?.
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Management of bone pain;
Establish the ? diagnosis
?/local ? to control the pain.
? to reduce the fracture risk.
May respond to chemo / ?(breast / prostate) therapy.
Prophylactic ? ? may be indicated to prevent pathological fractures.
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