Gout Flashcards
Prevalence of gout is around ?%, with a strong ?predominance (10:1).
Most common inflammatory arthritis in men over ?.
It is a pathological reaction of the joint/? tissues to presence of
? urate ? (MSUM) crystals.
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These preferentially deposit in the ? connective tissues in and around ? joints, initially favouring the ? limb.
It will classically first present the 1st ??? joint.
As the crystal deposits slowly increase, there is progressive involvement of
more ? sites, and the potential for development of secondary ?.
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? is not alone sufficient to cause gout, with ?% of ? subjects never developing gout.
Other risk factors are age, ? syndrome, high ? diet and high ? intake (predominantly ?- contains guanosine).
In over 90% of patients with primary gout, hyperuricaemia results from an
? isolated defect in uric acid ?, which means they cannot
increased ? excretion in response to a ? load.
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Secondary gout causes;
o Factors that impair ? of gout: ???, drugs (?/?),
hyper?, hyper?, ?thyroid
o Factors that increase ? of uric acid: ? conditions or
?/? - proliferative disorders
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Less than 1% may have a specific inherited ? defect of purine ?, which should be suspected if the gout develops below the age of
?, if there is a strong history of ? ? gout, or if there is uric acid ? in the ? tract.
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