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STEP 1 > SNS/PSNS effects > Flashcards

SNS/PSNS effects Flashcards

1
Q

Beta 1 blocker effect on Kidneys

A

↓ Renin

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2
Q

Beta 1 blocker effect on heart (3)

A

↓ HR
↓ Contractility
↓ Oxygen consumption

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3
Q

Beta 2 blocker effect on muscle vasculature

A

Vasospasm

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4
Q

Beta 2 blocker effect on

Lungs

A

Bronchoconstriction

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5
Q

Beta 2 blocker effect on liver

A

↓ Glycogenolysis
↓ Gluconeogenesis
*may cause hypoglycemia in diabetics

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6
Q

Effect of M1 stimulation on the brain

A

↑ Memory formation

↑ Cognitive functioning

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7
Q

Effect of M2 stimulation on the heart

A

↓ HR

↓ atrial contraction

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8
Q

Effect of M3 stimulation on peripheral vasculature

A

Smooth muscle relaxes
Vasodilation
Hypotention

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9
Q

Effect of M3 stimulation on lungs

A

Bronchoconstriction

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10
Q

Effect of M3 stimulation on bladder

A

Detrusor contraction

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11
Q

Effect of M3 stimulation on Eyes

A

Miosis (Pupillary sphincter muscle contraction)

Accommodation (Ciliary muscle contraction)

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12
Q

Effect of M3 stimulation on GI tract

A

↑ Peristalsis
↑ Salivary secretion
↑ Gastric secretion

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13
Q

Effect of M3 stimulation on skin

A

↑ sweat production

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14
Q

Effect of M3 inhibition on GI tract

A

Constipation
Dry mouth
↓ Gastric acid secretion

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15
Q

Effect of M3 inhibition on

Eyes

A

Mydriasis
Cycloplegia
+/– Acute angle Glaucoma

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16
Q

Effect of M3 inhibition on

Bladder

A

Detrusor Relaxation
Urinary retention
(full as a flask)

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17
Q

Effect of M3 inhibition on lungs

A

Bronchodilation

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18
Q

Anticholinergic clinical use

Scopolamine

A

Motion sickness

Sedation

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19
Q

Anticholinergic clinical use

Benztropine

A

Drug induced Parkinson’s

Sedation

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20
Q

Anticholinergic clinical use

Atropine

A

Heart Block
Sinus Bradycardia
(tachycardia)

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21
Q

Anticholinergic effects of
Atropine, Scopolamine
on secretions

A

↓ lacrimation, sweating, salivation, bronchial, GI secretions

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22
Q

Anticholinergic clinical use

Oxybutynin

A

Neurogenic spastic bladder

relaxes detrusor

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23
Q

Anticholinergic clinical use

ipratropium

A

COPD/ asthma

bronchodilation

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24
Q

Parasympathetic Nervous System has
___ Pre-synaptic Neurons
&
___ Post- synaptic Neurons

A

Long

Short

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25
Q

Sympathetic Nervous System has
___ Pre-synaptic Neurons
&
___ Post- synaptic Neurons

A

Short (SNS)

Long

26
Q

Somatic Nervous system controls

A

voluntary movement

27
Q

Autonomic Nervous system controls

A

involuntary actions

28
Q

All Pre-synaptic neurons release Ach and bind ___ receptors

A

Nicotinic

29
Q

Skeletal muscle contains what type of receptor

A

Nicotinic (ion channels)

30
Q

Sweat glands are innervated by what Nervous system?

A

Sympathetic

31
Q

The adrenal glands are innervated by what Nervous system?

A

Sympathetic

32
Q

Sweat Glands contain what type of receptor?

A

Muscarinic

33
Q

M3 receptors use what type of receptor

A

Gq coupled GPCR

34
Q

Beta 2 adrenergic receptors __ insulin secretion

A

↑

35
Q

Alpha 2 adrenergic receptors __ insulin secretion

A

↓

36
Q

M3 & Glucagon __ Insulin secretion

A

↑

37
Q

List the effects of Anticholinergic toxicity (aka Muscarinic or Ach antagonist)

A 
↑ Body temp (Hot as a Hare)
↓ secretions (Dry as a bone)
Flushed skin (Red as a beet)
Mydriasis/Cycloplegia (Blind as a bat)
Altered mental status (Mad as a hatter)
Constipation/Urinary retention (full as a flask)
Tachycardia (Fast as a fiddle)
38
Q

Why does anticholinergic toxicity cause Tachycardia?

A

↓ Vagal tone at the SA node

39
Q

Alpha 1 stimulation primary effects (3)

A

Peripheral Vasoconstriction
Internal Urethral Constriction
Pupillary Dilation

40
Q

Alpha 2 stimulation primary effects (2)

A

↓ Insulin release

↓ Intestinal motility

41
Q

Beta 1 stimulation primary effects (3)

A

↑ Cardiac Contractility
↑ HR
↑ Renin

42
Q

Beta 2 stimulation primary effects (2)

A

Peripheral Vasodilation
Bronchodilation
*Uterus relaxation (tocolysis)

43
Q

Muscarinic 2 stimulation primary effects (2)

A

↓ Cardiac Contractility

↓ HR

44
Q

Muscarinic 3 stimulation primary effects (6)

A 
Bronchoconstriction
↑ Insulin release
↑ Intestinal motility
Detrusor Contraction
Pupillary constriction
Peripheral Vasodilation (via NO)
45
Q

Alpha 1 stimulation causes what change in second messenger?

A

↑IP3

46
Q

Alpha 2 stimulation causes what change in second messenger?

A

↓cAMP

47
Q

Beta 1 stimulation causes what change in second messenger?

A

↑cAMP

48
Q

Beta 2 stimulation causes what change in second messenger?

A

↑cAMP

49
Q

M2 stimulation causes what change in second messenger?

A

↓cAMP

50
Q

M3 stimulation causes what change in second messenger?

A

↑IP3

51
Q

MOA:
Midodrine
Phenylephrine

A

alpha 1 agonist

52
Q

MOA: Clonidine

A

alpha 2 agonist

53
Q

MOA:
Doxazosin
Terazosin
Prazosin

A

alpha 1 antagonist

54
Q

alpha 1 & 2 antagonist

A

Phenoxybenzamine

55
Q

Beta agonist

A

Isoproterenol

56
Q

Beta 1 antagonist

A

Metoprolol

Atenolol

57
Q

Low dose Epinephrine favors what receptors

A

B1> B2>A1

58
Q

High dose Epinephrine favors what receptors

A

A1> B1> B2

59
Q

phenylephrine

A

alpha 1 agonist

60
Q

List the Cholinergic toxicity muscarinic and nicotinic effects.

A 
Diarrhea/ Diaphoresis
Urination 
Miosis
Bronchospasm/ Bradycardia
Emesis
Lacrimation
Salivation
Nicotinic effects:
Muscle weakness
paralysis
fasciculations

STEP 1 (88 decks)

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