Non-Hodkins Lymphomas Flashcards
Teens and young adults
t(8,14)
EBV
Burkitt Lymphoma
(B cell)
(8, B, and Burkitt all look similar)
BCL2 and BCL6 mutation
Most common type
Diffuse Large B cell Lymphoma
t(14,18) Heavy Ig (14) increased BCL2 (18) Waxing, Waning, Indolent
Follicular (Four-teen is Four-llicular)
B cell
BCL2’s function
Inhibit apoptosis
t(11,14)
Cyclin D1 (11) Heavy Ig (14)
Very aggressive presents late
Mantle cell lymphoma
(B cell)
*Mantle te Mata (kills you)
t(11,18) Associated with: chronic inflammation Sjrogrens Gastritis
Marginal zone
B cell
Aids defining illness
EBV
one ring-enhancing lesion
CNS lymphoma
B cell
HTLV
IVDU
Cutaneous lesion
Lytic Bone –> Hypercalcemia
T-cell lymphoma
(Japan –> Tokyo T- cell lymphoma)
Retro drugs and boning in Tokyo
Skin patches/Plaques
atypical CD4+ T cells (cerebriform nuclei)
intraepidermal neoplastic cell aggregates
Mycosis Fungiodes –> Sezary
Low yield
t(8,14) translocates what to heavy Ig chain (14)
c-myc
Presents with Jaw lesions in African children or mass in the abdomen (US) and associated with EBV
Burkitt
Pautirier microabscess
Mycosis Fungiodes –> Sezary
Biopsy of the spleen reveals reveals a lymph node–like appearance with abnormal germinal centers and stains positively for CD20 and bcl-2. All these features point toward
follicular lymphoma, a type of non-Hodgkin lymphoma (NHL).
Men
Diagnostic features include CD5 positivity and a t(11;14) translocation. This translocation leads to over expression of cyclin D1, a known proto-oncogene.
Mantle cell lymphoma
Burkitt lymphoma is a rare cancer of young adults that is associated with Epstein-Barr virus infection, and patients present with an abdominal mass or jaw lesion. Classic overexpression of ___
c-myc
t(8,14)
Translocation between chromosome 8 and the heavy arm of the Ig gene is highly prevalent
