Autoimmune

Question 1

Budesonide (glucocorticoids) reduces inflammation by binding to a cytosolic receptor, ______, and inhibiting proinflammatory transcription factors such as nuclear factor-kappa-B (NF-κB).

Answer 1

translocating into the nucleus

Question 2

Oral budesonide is useful in Crohn disease because it has high topical potency and less systemic adverse effects than other glucocorticoids (prednisone) due to

Answer 2

high first-pass metabolism

Question 3

Crohn disease with ileal resection or extensive ileal involvement can cause bile acid malabsorption/ impaired absorption of fat-soluble vitamins (A, D, E, K).

______ deficiency can result in impaired coagulation with easy bruising, large hematoma formation in deep tissues and joints after minor trauma, and prolonged bleeding after surgery.

Answer 3

Vitamin K

Question 4

can occur following administration of antigenic heterologous proteins such as chimeric monoclonal antibodies (eg, rituximab and infliximab) or nonhuman immunoglobulins (eg, venom antitoxins).

Answer 4

Serum sickness

Question 5

a type III hypersensitivity reaction to nonhuman proteins characterized by vasculitis resulting from tissue deposition of circulating immune complexes. Clinical findings include fever, pruritic skin rash, arthralgias, and low serum C3 and C4 complement levels.

Answer 5

Serum sickness

Question 6

Serum sickness is a type __ hypersensitivity reaction to nonhuman proteins characterized by vasculitis resulting from tissue deposition of circulating immune complexes. Clinical findings include fever, pruritic skin rash, arthralgias, and low serum C3 and C4 complement levels.

Answer 6

3

Question 7

Anti–double-stranded DNA antibodies and anti-Smith antibodies have lower sensitivity but higher specificity for

Answer 7

SLE

*Common laboratory: low C3 and C4 levels and elevated inflammatory markers (CRP, ESR)

Question 8

Immune-mediated destruction of the lacrimal &salivary glands

Answer 8

Sjogrens

Question 9

Positive anti-Ro (SSA) &/or anti-La (SSB)

Answer 9

Sjogrens

Question 10

Complications
Non-Hodgkin lymphoma
Corneal damage, dental caries

Answer 10

Sjogrens

Question 11

Anti-scl-70 (anti-DNA topoisomerase I)

Answer 11

Scleroderma (diffuse)

Question 12

Anti-histone

Answer 12

Drug Induced Lupus

Question 13

anti MPO/ p-ANCA

Answer 13

Ulcerative colitis

Question 14

Anti-hemidesmosome

Answer 14

Bullous Pemphigoid (Tense Blisters IgA)

Question 15

Anti-Desmoglein (anti-desmosome)

Answer 15

Pemphigus Vulgaris (Fatal IgG ABs)

Question 16

IgA anti- Transglutaminase

IgA anti- Endomysial

Answer 16

Celiac Disease

Question 17

Anti-Glutamic Acid Decarboxylase

Answer 17

DM 1

Question 18

Anti-centromere

Answer 18

Limited Scleroderma (Crest Syndrome)

Question 19

Anti-mitochondrial

Answer 19

Primary Biliary Cholongitis

Question 20

Anti-CCP

Answer 20

Rheumatoid Arthritis

Question 21

IgM antibody against IgG Fc region

Answer 21

RF

Question 22

Aphthous ulcers are the most common oral manifestation of this disease.

Answer 22

Chron’s

Question 23

Selective __ deficiency is usually asymptomatic, although it is associated with an increased risk for giardiasis and recurrent sinopulmonary infections caused by encapsulated bacteria

Answer 23

IgA

Question 24

In Sjogrens, patients typically have severe dry mouth (xerostomia) due to reduced saliva production, which can lead to an increased rate of

Answer 24

dental caries and other oral infections (eg, thrush)

Question 25

The increase in the neutrophil count , from ____ use, results from “demargination” of neutrophils previously attached to the vessel wall.

Answer 25

Glucocorticoid

Question 26

Necrotizing vasculitis of the upper and lower respiratory tract (causing nasal ulcerations, sinusitis, hemoptysis) and rapidly progressive glomerulonephritis—producing a variable degree of renal failure—is characteristic of granulomatosis with polyangiitis (Wegener). This disease is associated with C-ANCAs, which may target ___ proteinase 3.

Answer 26

neutrophil

Question 27

have a variety of effects like decreased proinflammatory cytokine (IL-1, interferon-gamma) production, increased anti-inflammatory cytokine (eg, IL-10) production, and impaired migration of leukocytes (eg, neutrophils) to sites of inflammation.

Answer 27

Glucocorticoids

*used to treat Sarcoidosis

Question 28

Histopathologic examination of the skin lesions reveals damaged small vessels with fibrinoid necrosis, perivascular neutrophilic inflammation, and nuclear debris (ie, leukocytoclastic vasculitis). Immunofluorescence reveals deposition of IgA and C3.

Answer 28

IgA Vasculitis

HSP

Question 29

Nasal mucosal ulcerations and glomerulonephritis and c-ANAC antibodies (pathognomonic) are most characteristic of _____.

Answer 29

Granulomatosis with polyangiitis (Wegener)

Question 30

Arthritis, Pleuritis (hurts to breath in), Pericarditis, Peritonitis, Thrombolic events, frequent pregnancy loss, seizures, antiphospholipid antibodies characteristics of

Answer 30

SLE