Portal HTN- GI Flashcards
Cirrhosis cause diffuse bridging fibrosis (via ____ cells) and regenerative _____ which disrupt normal architecture of liver;Increases the risk for _____
stellate
nodules
hepatocellular carcinoma
3 unique clinical findings of Cirrhosis
Juandice
Ascities
Splenomegaly
(JAS, girl, you’ve got cirrhosis)
Varices
Etiologies of Cirrhosis include alcohol, ______, chronic viral hepatitis (HCV), auto immune hepatitis, ______, genetic/metabolic disorders like _____ & _____
non alcoholic steatohepatitis
biliary disease
ARPKD & Alpha 1 antitrypsin deficiency
Cirrhosis is the number 1 cause of
Protal HTN
Etiologies of Portal HTN include cirrhosis, vascular obstruction like ___ & ____, and lastly, _____ infection
portal vein thrombosis
Budd-Chiari syndrome
Schistosomiasis
Thrombosis or compression of hepatic veins with centrilobular congestion and necrosis
Budd-Chiari syndrome
How can you tell its Budd-Chiari syndrome and not cirrhosis yet?
No JVD
May cause nutmeg liver (molted bumpy appearance)
Budd-Chiari syndrome
Budd-Chiari syndrome can be caused associated with (3)
Post-partum
Polycythemia Vera
Anything making you hypercoagulable (OCPs, Nephrotic syndrome, HCC)
Cirrhosis with PAS + globules
Alpha 1 antitrypsin deficiency
Dyspnea
Cirrhosis
Non-smoker
Alpha 1 antitrypsin deficiency
Caused by misfolded protein aggregates in the hepatocyte Rough Endoplasmic Reticulum
Cirrhosis from Alpha 1 antitrypsin mutation
Wilson’s disease (Elf)
Hemachromatosis
can cause
HCC
HCC is associated with what elevated marker
alpha fetoprotein
Tender Hepatomegaly
Polycythemia (increased RBC count)
Ascites
HCC