Rituximab , Cetuximab , Bevacizumab , Alemtuzumab , Trastuzumab

Question 1

Name the Monoclonal Antibodies used in treatment of Cancer

Answer 1

Rituximab
(“coronation ritual”)

Cetuximab
(“tusks”)

Bevacizumab
(“Beverage lady”)

Alemtuzumab
(“Alms”)

Trastuzumab
(“Tapestry weaver”)

Question 2

Rituximab MOA

Answer 2

Rituximab and Cetuximab are chimeric monoclonal antibodies
(“Chimera sigil”)

binds CD20 on B-cells
(“Grabbing “XX” straps”)

rituximab depletes B cells (binds CD20)
(“Pulling down antibody archer”)

Question 3

Rituximab can be used to treat …

Answer 3

treats chronic lymphocytic leukemia (CLL)
(“Chronic tapestry with antibody archers and T knights”)

• rituximab treats rheumatoid arthritis
• disease modifying anti-rheumatic drug – DMARD

(“Rheumatic lantern”)

-is useful for immunosuppressive therapy

(e.g. microscopic polyangiitis, Wegener’s granulomatosis)
(“Torn antibody”)

Question 4

Rituximab Side Effects

Answer 4

can cause immunosuppression and increased risk of infection
(“Immunosuppressed cane”)

-may be associated with a higher risk of progressive multifocal leukoencephalopathy (PML)
(“White laurel leaves”)

-can cause an infusion reaction (e.g. headache, fever, skin rash, pruritus, dyspnea, hypotension)
(“Swollen cherub with ivy”)

-chimeric antibodies (e.g. rituximab, rarely cetuximab) can cause serum sickness e.g. fever, rash, arthralgia within 7-10 days
(“Delayed onset poisoning”)

Question 5

Cetuximab MOA

(“Tusks”)

Answer 5

binds the epidermal growth factor receptor (EGFR)

• EGFR is a receptor tyrosine kinase
  (“Tire swing”)

(“Giraffe”)

Question 6

Cetuximab can treat …

Answer 6

treats solid tumors

• e.g. colorectal cancer, squamous cell carcinoma

(“Cracked crab”)

Question 7

Cetuximab Side Effects

Answer 7

can cause a papulopustular acneiform rash
(“Red spots”)

Question 8

Bevacizumab MOA

(“Beverage Lady”)

Answer 8

binds VEGF

• inhibits growth of blood vessels in tumors binds VEGF
  (“Chopping vessels”)

(“Chopped vegetables”)

Question 9

Bevacizumab can treat …

Answer 9

treats metastatic tumors

• e.g. colorectal cancer, squamous cell carcinoma
  (“Cracked crab”)

-treats wet macular degeneration
(“Wet center of retina pillow”)

Question 10

Bevacizumab Side Effects

Answer 10

-can cause bleeding
(“Blood spatter”)

-increases the risk for thrombotic events
(“Ice clots”)

Question 11

Alemtuzumab MOA

(“Alms”)

Answer 11

-binds CD52 on B and Tcells

depletes B and T cells (binds CD52)
(“Pulling down antibody archer and T knight”)

(“52 pattern”)

Question 12

Alemtuzumab can treat…

Answer 12

treats chronic lymphocytic leukemia (CLL)
(“Chronic tapestry with antibody archers and T knights”)

Question 13

Trastuzumab MOA

(“Tapestry weaver”)

Answer 13

binds epidermal growth factor receptor 2

• HER2, c-erbB2
• ​HER2 is a receptor tyrosine kinase
  (“Tire swing”)

(“Her 2 babies”)

Question 14

Trastuzumab can treat …

Answer 14

treats HER2 positive breast cancer
(“Crab bra”)

Question 15

Trastuzumab can cause …

Answer 15

trastuzumab can cause cardiotoxicity

• e.g. decreased LVEF, heart failure
  (“Unraveling heart”)