Atypical Antidepressants

Question 1

Name Atypical Antidepressants

Answer 1

Bupropion (Unicyclic)
(“blacky pro ball player”)

Mirtazapine (Tetracyclic)
(“mirth and misery” happy/sad mask)

Trazodone
(“cheerleader with Trombone”)

Question 2

Bupropion MOA

Answer 2

Inhibits reuptake of Norepinephrine and Dopamine via NET/DAT (“NET DAT ball pro”)

**no effects on serotonin !- no smiley symbols**

Question 3

what can Bupropion be used for ?

Answer 3

-atypical antidepressant that used for treatment of depression associated with hypersomnolance (daytime sleepness) since it has CNS activating effects via NE
(“depressed blue shirt boy aroused from sleep”) \

-can be used for treatment of tobbaco dependence
(“pros don’t smoke” sign)

-
Bupropion is less likely to cause weight gain
(“stay fit lose weight” sign )

-Bupropion doesn’t cause sexual dysfunction
(“kissing couple below the basket”)

Question 4

what are the adverse effects of Bupropion ?

Answer 4

• can induce Seizures
• Bupropion is contraindicated in Bulimia since it can lead to seizures (“shaking popcorn binge snacker”)
• Bupropion is contraindicated in anorexia nervosa since it can lead to seizures
  (“shaking skinny blacky player”)

(“shaking proball player dunking”)

Question 5

Mirtazapine MOA

(“Mirth and Misery”)

Answer 5

-Blocks 5HT-2/5HT-3 receptors
(“retired shirts number 52 and 53 hanging “)
——————————————————————————–
-Mirtazapine blocks H1 receptors leading to

• weight gain - good for depressed *anorexic
• ​sedation - good for depressed with *insomnia

​——————————————————————————–
-blocks α2 receptors leading to increased 5HT/NE
(“extinguished double candle above cam screen and released smiley/compass balloons”)
​

Question 6

what can Mirtazapine be used for ?

(“Mirth and misery”)

Answer 6

• Atypical Antidepressants can be used as 1st line treatment of depression (“happy/sad mask” on cam screen):
• some patients with depression are adminstered with Mirtazapine as 1st line of treatment when the adverse effects are actually desirable e.g.- elderly/anorexic {usually SSRIs}

​-Mirtazapine doesn’t cause sexual dysfunction
(“kiss-cam next to mirth/misery cam”)

Question 7

Trazodone MOA

Answer 7

-Trazodone is a Serotonin Modulator
(“marching drum player modulates serotonin smiley drum”)
-minimal effects on NE/Dopamine therefore Trombone far from “NET DAT BALL”
——————————————————————————–
-blocks 5HT-2 Receptors as well as inhibits reuptake
(“marching drum player wearing retired shirt 52”)
——————————————————————————–
-Trazodone is α1 antagonist receptors
(“lady tromboner holding single extinguished candle “)
——————————————————————————–
-inhibits H1 histamine receptors
(“Bee swatter player”)

Question 8

Trazodone adverse effects

Answer 8

-Trazodone can cause Priapism
(“TrazaBONER” male tromboner holding trombone in erected position)

-can cause orthostatic hypotension {via α1 antag.}
(“coach fainting on floor”)

-can cause Sedation {via H1 antagonism}
(“sleeping players on bench”)

-can cause sexual dysfunction
(“trombone player rejected by female player because he is out of her league yo’”)

-can cause Serotonin Syndrome
(“pile of smiley balls on floor”)