Loop Diuretics Flashcards
1
Q
Name the Loop Diuretics
A
THE MOST EFFICIENT DIURETICS EVA !
Furosemide (SULFA)
Ethacrynic acid (NON-SULFA)
2
Q
Loop Diuretics MOA
A
Site of action : TAL
- impermeable to water -diluting segment
(“secured water in car”) - Blocks NKCC transporter and cancels positive luminal charge
- K+ no longer effluxes from cells thus promote excretion of Mg+2 and Ca+2
- induce expression of COX-2 which synthesizes prostaglandins
- prostaglandins dilate afferent arteriole, increase RBF and enhance diuretic action
3
Q
Loops diuretics are used for …
A
- 1st line for the symptomatic treatment of acute decompensated heart failure
- 1st line treat symptoms of pulmonary edema in an acute heart failure exacerbation
- loop diuretics treat ascites in liver failure
- can be useful in the treatment of HTN
4
Q
can loop diuretics prolong the the life of the heart ?
A
No.
5
Q
which group of drugs may interfere with the actions of Loop Diuretics and why ?
A
NSAIDs - decrease prostaglandins synthesis ,thus interfere with the actions of loop diuretics
6
Q
Side Effects of Loop Diuretics
A
- loop diuretics may cause hypokalemia
- prolonged use of loop diuretics can cause hypomagenesmia
- Loop diuretics can cause hypocalcemia (rare)
- can cause dose related hearing loss
- Interstitial nephritis can be caused by loop diuretics
- loop diuretics can cause hyperuricemia, may lead to gouty arthritis
- can cause contraction alkalosis