Loop Diuretics Flashcards

1
Q

Name the Loop Diuretics

A

THE MOST EFFICIENT DIURETICS EVA !

Furosemide (SULFA)

Ethacrynic acid (NON-SULFA)

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2
Q

Loop Diuretics MOA

A

Site of action : TAL

  • impermeable to water -diluting segment
    (“secured water in car”)
  • Blocks NKCC transporter and cancels positive luminal charge
  • K+ no longer effluxes from cells thus promote excretion of Mg+2 and Ca+2
  • induce expression of COX-2 which synthesizes prostaglandins
  • prostaglandins dilate afferent arteriole, increase RBF and enhance diuretic action
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3
Q

Loops diuretics are used for …

A
  • 1st line for the symptomatic treatment of acute decompensated heart failure
  • 1st line treat symptoms of pulmonary edema in an acute heart failure exacerbation
  • loop diuretics treat ascites in liver failure
  • can be useful in the treatment of HTN
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4
Q

can loop diuretics prolong the the life of the heart ?

A

No.

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5
Q

which group of drugs may interfere with the actions of Loop Diuretics and why ?

A

NSAIDs - decrease prostaglandins synthesis ,thus interfere with the actions of loop diuretics

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6
Q

Side Effects of Loop Diuretics

A
  • loop diuretics may cause hypokalemia
  • prolonged use of loop diuretics can cause hypomagenesmia
  • Loop diuretics can cause hypocalcemia (rare)
  • can cause dose related hearing loss
  • Interstitial nephritis can be caused by loop diuretics
  • loop diuretics can cause hyperuricemia, may lead to gouty arthritis
  • can cause contraction alkalosis
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