methotrexate ,5 fluorouracil , hydroxyurea

Question 1

Methotrexate MOA

Answer 1

-inhibition of DHF reductase
(“meat sticks chef trying to replace the folate leafs”)

Question 2

Methotroxate is useful in treating ...

Answer 2

-cancers
(“Cracked crab”)

-MTX with misoprostol used as abortifacient and ectopic pregnancy

(“Empty uterus backpack”)
(“baby keychain on the side”)

-invasive molar pregnancy, trophoblastic tumors and choriocarcinoma
(“Mole keychain”)

-Methotrexate treats psoriasis
(“Silver knee/elbow pads”)

-Methotrexate is first line treatment for rheumatoid arthritis or DMARD
(“Joint lantern with flame”)

-used for immunosuppressive therapy such as IBD, SLE, vasculitis, dematomyositis
(“Torn antibody latern”)

Question 3

Methotrexate Side Effects

Answer 3

-folate deficiency
(“Foliage falling”)

-megaloblastic anemia
(“Blasting firework lantern”)

-pancytopenia, myelosuppression
(“Falling pan of sushi:”)

-immunosuppressed have increased risk for infection
(“Cane”)

-lung fibrosis (restrictive lung dz)
(“Fibrotic lung bonsai”)

• hepatotoxicity, monitor LFTs
  (“Liver spot on apron”)

-causes baldness
(“Bald guy”)

• mucositis
  (“Guy eating hot meat stick”)

Question 4

what is the antidote for Methotroxate toxcity ?

Answer 4

folinic acid

(“Lucky feline”)

Question 5

5’-Fluorouracil MOA

Answer 5

inhibits thymidylate synthase to block thymidine production

• increase dUMP via inhibition of thymidylate synthase
  (“Buildup of dumpling plates”)

(“Full guy”)

Question 6

5’-Fluorouracil Side Effects

Answer 6

-diarrhea
(“Stained pants”)

-photosensitivity and rash
(“Sensitive photos”)

-increases myelosuppression and infection
(“Falling pan of sushi”)

Question 7

5 -Fluorouracil Antidote

Answer 7

NO ANTIDOTE! MUAHAHAHAHA!!!!!!!

(“Knocked over cat”)

Question 8

Hydroxyurea MOA

(“Hydro rock area”)

Answer 8

ribonucleotide reductase inhibitor, blocks thymidine synthesis

• ribonucleotide reductase converts UDP to deoxy-UDP
  (“Crossed out OXY”)
• UDP (uridine diphosphate) is precursor to pyrimidine nucleosides
  (“UDP sign”)

(“inhibited wait list waitress”)

Question 9

Hydroxyurea can treat …

Answer 9

sickle cell anemia

• increase HbF, protection against HbS
  (“Raised baby with Hb coin”)

(“Zen sickle”)

Question 10

Hydroxyurea Side Effect

Answer 10

myelosuppression and increased infection side effect
(“Falling pan of sushi”)