Cytotoxic platinum analogs

Question 1

Name Cytotoxic Platinum analogs

Answer 1

• *Cis**platin
• *Carbo**platin
• *Oxali**platin

Question 2

Cisplatin
Carboplatin
Oxaliplatin

MOA

Answer 2

bind DNA and form intrastrand and interstrand cross-links

(“Cross-linked helix necklace”)

Question 3

Cisplatin
Carboplatin
Oxaliplatin

can treat …

Answer 3

treat various solid malignancies

• non-small cell lung cancer,
• ​ small cell lung cancer,
• ​ testicular cancer,
• ​ovarian cancer, bladder cancer

(“Crumpled crab”)

Question 4

Cisplatin
Carboplatin
Oxaliplatin

Side Effects

Answer 4

can cause ototoxicity → especially cisplatin

• sensorineural hearing loss, tinnitus
  (“Ototoxic earrings”)

can cause neurotoxicity→especially cisplatin

• peripheral neuropathy
  (“Neuropathic gloves”)

can cause nephrotoxicity → especially cisplatin

• acute kidney injury
  (“Nephrotoxic purse”)
• ​amifostine (an organic thiophosphate) can prevent cisplatin-induced nephrotoxicity (“Amethyst”) → scavenges free radicals produced by cisplatin in the kidney (“Free, rare”)
• ​IV saline diuresis prevents cisplatin-induced nephrotoxicity
  (“saline fluids”)

-can cause acute tubular necrosis

• muddy brown casts
  (“Muddy drain tube”)

-can cause immunosuppression and increased risk of
infection→especially carboplatin
(“Immunosuppresed cane”)

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-can cause myelosuppression→especially carboplatin (“Depleted bone jewelry box”)

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