Class III Antiarrhythmics Flashcards

1
Q

Names of Class III Antiarrhytmics

A

-Amiodarone
(“tres AMIGOs”)

-Tilide suffix (blue chica holding “till i die” sign )

  • DOFE tilide
  • ​IBU tilide

​-Sotalol (“Soda on table”)

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2
Q

Class III Antiarrhytmics MOA

A

-block K+ channels prolonging phase 2 and 3 of the cardiac action potential→prolonged refractory period
(“Singer pushing away the Banana curtain”)

-*_Amiodarone_* shares properties of **class I, II, III,** and **IV** antiarrhythmics.
(grafiiti on wall says "uno, dos, tres, quattro”)

-Sotalol is also a beta blocker
(“Muted beta bugle and soda bottles”)

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3
Q

Class III Antiarrhytmics can be used to treat …

A

-treat both supraventricular arrhythmias and also ventricular arrhythmias
(“Heart candles illuminated on top and bottom”)

-treat atrial fibrillation and flutter
(“Irregularly irregular signal on TV”)

-can restore and maintain normal sinus rhythm in atrial fibrillation and flutter
(“green shirt old fart converting the signal using remote control “)

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4
Q

Amiodarone Side Effects

A

-many neurologic side effects -tremor, ataxia, peripheral neuropathy, sleep disturbances
(“sombrero with Skulls”)

-can cause grey corneal deposits
(“singer with Gray sunglasses”)

-can cause hyper or hypo-thyroidism
(“band members wear Big and small bowties

-can cause pulmonary fibrosis
(“Fibrotic lung embroidery on singer’s blazer “)

-lung fibrosis causes restrictive lung diseases
(“singer has tight button in his blazer”)

-can induce heart failure
(“Trampled failing heart balloon”)

-can cause hypersensitivity hepatitis
(“Liver spot on cow”)

-can cause gray blue skin discoloration
(“Mariachi band wearing Grey blue outfits”)

-inhibits the cytochrome P450 - drugs like warfarin and statins may increase

(“Broken chrome bumper”)

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5
Q

Sotalol , Dofetilide , Ibutilide (Also Amiodarone)
Side Effects

A

-can induce dose related torsade’s
(“twisted torsades streamer”)

(although all type III antiarrhythmics can widen the QT interval)

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6
Q

which lab tests should be preformed when starting Amiodarone therapy ?

A
  • *Pulmonary** Function Test
  • *Thyroid** Function Test
  • *Liver** Function Test
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7
Q
A
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