Class III Antiarrhythmics Flashcards
Names of Class III Antiarrhytmics
-Amiodarone
(“tres AMIGOs”)
-Tilide suffix (blue chica holding “till i die” sign )
- DOFE tilide
- IBU tilide
-Sotalol (“Soda on table”)
Class III Antiarrhytmics MOA
-block K+ channels prolonging phase 2 and 3 of the cardiac action potential→prolonged refractory period
(“Singer pushing away the Banana curtain”)
-*_Amiodarone_* shares properties of **class I, II, III,** and **IV** antiarrhythmics. (grafiiti on wall says "uno, dos, tres, quattro”)
-Sotalol is also a beta blocker
(“Muted beta bugle and soda bottles”)
Class III Antiarrhytmics can be used to treat …
-treat both supraventricular arrhythmias and also ventricular arrhythmias
(“Heart candles illuminated on top and bottom”)
-treat atrial fibrillation and flutter
(“Irregularly irregular signal on TV”)
-can restore and maintain normal sinus rhythm in atrial fibrillation and flutter
(“green shirt old fart converting the signal using remote control “)
Amiodarone Side Effects
-many neurologic side effects -tremor, ataxia, peripheral neuropathy, sleep disturbances
(“sombrero with Skulls”)
-can cause grey corneal deposits
(“singer with Gray sunglasses”)
-can cause hyper or hypo-thyroidism
(“band members wear Big and small bowties
-can cause pulmonary fibrosis
(“Fibrotic lung embroidery on singer’s blazer “)
-lung fibrosis causes restrictive lung diseases
(“singer has tight button in his blazer”)
-can induce heart failure
(“Trampled failing heart balloon”)
-can cause hypersensitivity hepatitis
(“Liver spot on cow”)
-can cause gray blue skin discoloration
(“Mariachi band wearing Grey blue outfits”)
-inhibits the cytochrome P450 - drugs like warfarin and statins may increase
(“Broken chrome bumper”)
Sotalol , Dofetilide , Ibutilide (Also Amiodarone)
Side Effects
-can induce dose related torsade’s
(“twisted torsades streamer”)
(although all type III antiarrhythmics can widen the QT interval)
which lab tests should be preformed when starting Amiodarone therapy ?
- *Pulmonary** Function Test
- *Thyroid** Function Test
- *Liver** Function Test