16. Clindamycin. Streptogramins. Oxazolidinones Flashcards
Clindamycin
bacterial 50s ribosomal subunit, inhibiting translocation
Bacteristatic
- Activity against staph and strep
- treats S.Pyogenes (GAS) and soft tissue infections (cellulitis)
Activity against MRSA
-Anaerobe activity
Lung stains with holes: excellent penetration into abscesses
treats oral infections and aspiration pneumonia caused by Bacteroides fragilis
activity against clostridium perfringens
topical clindamycin treats moderate to severe inflammatory acne
Uterus Machine: clindamycin plus gentamicin (gently cleaning the uterus) treats polymicrobial female genital tract infection.
Judo practitioner with Sai: gentamicin paired with clindamycin for broad coverage
-treats bacterial vaginosis from gardenella vaginallis
causes pseudomembranous colitis caused by C.Diff
Streptogramins
Streptogramins A + B
(A= Dalfopristin | B= Quinupristin)
Protein synthesis inhibitor - bind to different sites on the S50 ribosome
By themselves, streptogramins A and B are bacteriostatic.
Together bactericidal.
Given in mixture of 70:30 (A:B)
- A - disrupts elongation
- B - Releases incomplete peptide chains Long PAE
-G+ive cocci (also MDR strains)
-intracellular bacteria,
E.faecium and VRE
- IV
- Inhibits CYP3A4
-Infusion related phlebitis,
hyperbilirubinemia,
Arthralgia-myalgia.
Oxazolidinones
Linezolid
- binds reversibly to 50s ribosome, inhibiting peptide bond formation and halting translation
- activity against gram positive bacteria (staph, strep, enterococcus)
- MRSA activity
- treats nosocomial MRSA infections (hospital acquired pneumonia)
- activity against vancomycin resistant bacterial strains
- activity against **vancomycin enterococcus
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Broken plates: thrombocytopenia
Cut security camera wire: optic neuropathy ( and peripheral neuropathy)
-stocking-glove peripheral neuropathy
Happy face: serotonin syndrome
(weak inhibitor of MAOI, so can cause serotonin syndrome)
