Cladribine, Cytarabine, Gemcitabine

Question 1

Cladribine, Cytarabine, Gemcitabine MOA

Answer 1

-inhibit DNA polymerase → inhibit the S phase of the cell cycle

(“Cracked replication fork”)
(“Stone Phase”)

• cytarabine and gemcitabine are pyrimidine analogs
  (“Pyrimidine shapes”)
• ​cladribine is a purine analog
  (“Purine shaped hammer”)

Question 2

Cladribine can treat …

Answer 2

hairy cell leukemia

(“Hairy caveman”)

Question 3

Cytarabine can treat …

Answer 3

only active against hematologic malignancies

(“Scratched out antibody archers and T-cell swordsman”)

• AML
• ​ non-Hodgkin lymphoma

Question 4

Gemcitabine can treat…

(“gems inside geode”)

Answer 4

• active against both hematologic malignancies and
• *solid** tumors

(“Cracked crab fossil on solid rocks”)

Question 5

Cladribine, Cytarabine, Gemcitabine Side Effects

Answer 5

-can cause immunosuppression and increased risk of infection
(“Immunosuppressed cane”)

-can cause myelosuppression
(“Broken marrow”)