ACEi Flashcards

1
Q

Name the ACE inhibitors

A
  • *-PRIL**
  • *CAPTO/**pril
  • *ENALA/**pril
  • *RAMI/**pril
  • *LISINO/**pril
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2
Q

ACE inhibitors MOA

A

inhibit ACE ⇒ATI is not converted to ATII

→ counteracts ATII effects

  • dilate efferent arteriole → decrease GFR
  • ​decrease Aldosterone Release →decrease Na+ reabsorption (natiuresis)
  • ​decrease pressor effects of ATII
    (“floppy red suspenders”)
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3
Q

ACE inhibitors are used to treat …

A

-1st line treatment for CHF
(“failing heart balloon”)

-used in myocardial infarction
(“mandolina player playin dem Broken heart strings”)

-1st line agents used for HTN
(“High pressure candy pipes”)

-slow the progression of diabetic nephropathy
(“Diasweeties Candy shop”)

  • ACEi reduce Mortality
    (“Angel above le cross”)
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4
Q

which patients should be started on ACEi therapy ?

A

-patients with albuminuria and BP > 130/80
(“albums in diasweeties candy shop”)

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5
Q

what side effects might ACEi cause ?

A

-can cause significant hypotension and syncope in patients with high renin levels (in heart failure)
(“fainting poker player with floppy red suspenders”)

-can cause hyperkalemia due to decreased aldosterone levels
(“raised banana daquiri”)

-dry cough due to an increase of bradykinin
(“coughing dealer”)

-ACE increases the risk of fetal hypotension
(“Tarantula on mama’s back”)

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6
Q

when are ACEi contraindicated and why ?

A
  • ACE inhibitors are contraindicated inhereditary angioedema ( to C1 esterase deficiency) due to increased Bradykynin activity .
  • ACE inhibitors are contraindicated in bilateral renal artery stenosis due to further decrease in GFR
  • use of ACEi can precipitate acute renal failure charachterized by persistent increase in creatinine levels-azotemia
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7
Q

which drugs should be avoided during ACEi therapy ?

A

NSAIDs should be avoided since they inhibit the actions of prostaglandins and bradykynin , causing vasoconstriction of afferent arteriole→GFR decrease

  • can precipitate acute kidney injury
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8
Q

in case of Hereditary angioedema , which drugs can replace ACEi therapy ? why ?

A

ARBs can be used as a replacement therapy since they don’t affect bradykynin serum levels

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9
Q

Name the ARBs

A

-SARTAN (chair says “SoRry TAkeN”)

LO/ sartan
CANDE/ sartan
VAL/ sartan

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10
Q

MOA OF ARBs

A

Angiotensin II receptor blockers

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11
Q

Possible side effects of ARBs

A

- Hyperkalemia (“banana daquiri on taken chair”)

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12
Q

Name a drug which can directly inhibit renin

A

Aliskiren

(“high limit-high risk slots”)

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13
Q

name a possible side effect of Aliskiren ?

A

Hyperkalemia
(“slot machine showing 3 bananas”)

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