ACEi Flashcards
Name the ACE inhibitors
- *-PRIL**
- *CAPTO/**pril
- *ENALA/**pril
- *RAMI/**pril
- *LISINO/**pril
ACE inhibitors MOA
inhibit ACE ⇒ATI is not converted to ATII
→ counteracts ATII effects
- dilate efferent arteriole → decrease GFR
- decrease Aldosterone Release →decrease Na+ reabsorption (natiuresis)
- decrease pressor effects of ATII
(“floppy red suspenders”)
ACE inhibitors are used to treat …
-1st line treatment for CHF
(“failing heart balloon”)
-used in myocardial infarction
(“mandolina player playin dem Broken heart strings”)
-1st line agents used for HTN
(“High pressure candy pipes”)
-slow the progression of diabetic nephropathy
(“Diasweeties Candy shop”)
- ACEi reduce Mortality
(“Angel above le cross”)
which patients should be started on ACEi therapy ?
-patients with albuminuria and BP > 130/80
(“albums in diasweeties candy shop”)
what side effects might ACEi cause ?
-can cause significant hypotension and syncope in patients with high renin levels (in heart failure)
(“fainting poker player with floppy red suspenders”)
-can cause hyperkalemia due to decreased aldosterone levels
(“raised banana daquiri”)
-dry cough due to an increase of bradykinin
(“coughing dealer”)
-ACE increases the risk of fetal hypotension
(“Tarantula on mama’s back”)
when are ACEi contraindicated and why ?
- ACE inhibitors are contraindicated inhereditary angioedema ( to C1 esterase deficiency) due to increased Bradykynin activity .
- ACE inhibitors are contraindicated in bilateral renal artery stenosis due to further decrease in GFR
- use of ACEi can precipitate acute renal failure charachterized by persistent increase in creatinine levels-azotemia
which drugs should be avoided during ACEi therapy ?
NSAIDs should be avoided since they inhibit the actions of prostaglandins and bradykynin , causing vasoconstriction of afferent arteriole→GFR decrease
- can precipitate acute kidney injury
in case of Hereditary angioedema , which drugs can replace ACEi therapy ? why ?
ARBs can be used as a replacement therapy since they don’t affect bradykynin serum levels
Name the ARBs
-SARTAN (chair says “SoRry TAkeN”)
LO/ sartan
CANDE/ sartan
VAL/ sartan
MOA OF ARBs
Angiotensin II receptor blockers
Possible side effects of ARBs
- Hyperkalemia (“banana daquiri on taken chair”)
Name a drug which can directly inhibit renin
Aliskiren
(“high limit-high risk slots”)
name a possible side effect of Aliskiren ?
Hyperkalemia
(“slot machine showing 3 bananas”)