Ganciclovir , Valganciclovir Foscarnet , Cidofovir

Question 1

Ganciclovir MOA

Answer 1

Is a guanosine analog,
(“G purines in the background”)

→converted to ganciclovir monophosphate by a virus encoded kinase (UL97)
(“Market worker with P label gun”)

→converted to ganciclovir triphosphate by cellular kinase
(“Customers with p label guns”)

→Ganciclovir triphosphate incorporates into replicating viral DNA, halting synthesis
(“Grocery jam”)

Question 2

Valganciclovir benfit over Ganciclovir …

Answer 2

has better oral bioavailability

(“Open mouth”)

Question 3

Valganciclovir /Ganciclovir are indicated when

Answer 3

in high-risk solid organ and bone transplant recipients
(“Organs on ice”)

Question 4

Valganciclovir /Ganciclovir side effect

Answer 4

are associated with bone marrow suppression
(“Eaten marrow”)

• myelosuppression may be additive in patients receiving zidovudine
  (“Princess Izoide”)

Question 5

Foscarnet Side Effects

Answer 5

may induce renal insufficiency
(“Spilled kidney beans”)

may cause hypocalcemia
(“Broken milk bottle”)

may cause hypomagnesium
(“Falling magnets”)

may cause hypokalemia
(“Banana peel”)

may cause siezures
(“Shaking”)

Question 6

Cidofovir Side Effects

Answer 6

nephrotoxicity, leading to proteinuria, azotemia, and metabolic acidosis

• probenecid blocks the tubular secretion of cidofovir, limiting its toxic effects

(“Probation officer cid stoping the kidneys from falling and preventing the drug punk from getting alcohol”)

(“Broken kidney”)