prelim lesson 4 cell part 2 Flashcards
Chromosome means: chroma - __; some - __
color; body
seen during metaphase stage of mitosis
Chromosomes
in 1875 discovered thread-like structures which appeared during cell division.
E. Strasburger
coined the term chromosome first time in 1888.
Waldeyer
is found in somatic cell and is represented by __
somatic chromosome number; 2n (Diploid).
is half of the somatic chromosome
numbers and represented by ___
gametic chromosome number; n (Haploid).
The two copies of chromosome are ordinarily identical in morphology,
gene content and gene order, they are known as
homologues chromosomes.
that control characters other than sex characters or carry
genes for somatic characters.
Autosomes
(2N where N- chromosome number) have two homologous copies of each chromosome.
Diploid cells
body cells of animals are.
diploid
(N) have only one copy of each chromosome.
- Haploid cells
(the shorter of the two)
(the longer).
p
q
is the most suitable stage for studies on chromosome morphology.
Mitotic metaphase
Chromosomes are thin, coiled, elastic, thread-like structures during the
interphase
Each metaphase chromosome appears to be longitudinally divided into two identical parts each of which is called
chromatid
Both the chromatids of a chromosome appear to be joined together at a
point known as
centromere
the two chromatids making up a chromosome are produced
through replication of a single chromatid during synthesis (S) phase of interphase, they are referred to as
sister chromatids
the chromatids of homologous chromosomes are known as
non-sister chromatids
Each chromosome has a constriction
point called the
centromere
which divides the
chromosome into two sections or arms.
Kinetochore
The p arm is named for “__” meaning “__”;
petite; small
the q arm is named __
because it follows p in the alphabet.
q simply
The two ends of a chromosome
are known as
telomeres,
Useful in identifying a
chromosome from a set.
SECONDARY CONSTRICTION
between
the secondary constriction and
nearest telomere and chromosomes
that possess this region called as
satellite chromosome or sat
chromosome.
A small chromosomal segment
separated from the main body of the
chromosome by a secondary
constriction is called
Satellite.
the longest and thinnest during interphase
(resting stage) and hence not visible under light microscope.
chromosomes
is NOT proportional to the number of genes present
on the chromosome.
Chromosome size
Chromosomes are classified according
to the centromere position:
- At one end: Acrocentric
- Closer to one end: Submetacentric
- Middle: Metacentric
- Terminal: Telocentric
midway
between each end and thereby two
arms are roughly equal in length.
centromere
take V
shape during anaphase.
Metacentric chromosome
is located on one side
of the central point of a
chromosome.
Submetacentric Chromosome
submacentric chromosome may
be___or ___ during anaphase.
J or L shaped
`close to
one end of chromosomes.
Acrocentric Chromosome
(The “acro-“ in acrocentric
refers to the Greek word for “___”).
peak
is so short that is
hard to observe, but still present.
p (short) arm
may be
rod shape during anaphase.
Acrocentric chromosome
(at terminal part of chromosome)
Telocentric Chromosome
MEMORIZE!
* Acentric: without any centromere
* Mono centric: with one
centromere
* Dicentric : with two centromeres
* Polycentric: with more than two
centromeres
MEMORIZE!
* Acentric: without any centromere
* Mono centric: with one
centromere
* Dicentric : with two centromeres
* Polycentric: with more than two
centromeres
The DNA double helix in the cell
nucleus is packaged by special
proteins termed
histones
The formed protein/DNA complex is
called
chromatin.
The structural entity of chromatin is
the
nucleosome
Basic unit of DNA packaging in eukaryotes
NUCLEOSOME
147 base pairs of DNA wrapped in
1.67 left-handed superhelical turns
NUCLEOSOME
Transcriptionally inactive
HETEROCHROMATIN
Often (but not always) under active transcription
EUCHROMATIN
Regular sequence of events
that produce new cells.
CELL CYCLE
Pre-requisite stage before a cell
undergoes mitosis
INTERPHASE
This phase is where the cell spends
most of its time, specifically 20 hours
a day.
INTERPHASE
Where the cell grows and functions normally
GAP 1 PHASE (G1)
Not considered to be part of interphase
GAP 0 PHASE (G0)
Cell cycle activities may be temporarily or permanently
suspended
GAP 0 PHASE (G0)
can occur in S phase.
Genetic Mutation:
makes DNA strands linear, straight, long, uncoiled,
thin, and not condensed.
HISTONE:
makes DNA strands coiled, crumpled, and condensed to avoid unnecessary replication/duplication
PROTAMINE:
Is linear, a higher concentration of Histone, in contrary to
that of Protamine, is observed.
S phase
Period of preparation for mitosis
interphase
CDK-1 means?
cyclin derived kinase-1
cell division cycle expressed gene;
CDC-2
pre-MPF
pre-maturation promoting factors
Karyokinesis came from two Greek words: _____ and
___;
Mitosis came from __ (thread: pertaining to chromatin) and ___ (process/condition/status).
Karyon(nucleus);Kinesis (movement)
Mitos;Osis
is defined as the nuclear division of
biological cells.
karyokinesis-mitosis
Period of cell division
MITOSIS
first phase of mitosis,
PROPHASE
The complex of DNA and
proteins contained in the
nucleus,
chromatin
increases making the DNA strands of the cell start to condense, to contract, and to coil (identifier that the cell is at
prophase stage).
Protamine concentration
the cell proceeds to which occurs before metaphase.
Prometaphase:
chromosomes
condense and move
together, aligning in the
center of the dividing cell.
METAPHASE
The process that separates
the duplicated genetic
material carried in the
nucleus of a parent cell into
two identical daughter
cells.
ANAPHASE
Each daughter cell
receives half of all doubled
chromosome material and thus
maintains the same number of
chromosomes as the mother
cell.
TELOPHASE
Indirect process required by Mitosis; Condition of cytoplasm division.
CYTOKINESIS
The cell division that takes place in the germ cells to generate
male and female gametes,
MEIOSIS
The cells produced are HAPLOID,
MEIOSIS
- Came from two Greek words: __ (to reduce, to diminish,
a lessening) and Osis (process/condition/status);
Meion
Each of the PMAT of meiosis is intervened by a real resting stage called ____ which lasts for 2 to
3 hours.
INTERKINESIS
increase in histone
concentration.
Leptotene/Leptonema
synapsis of
homologous chromosomes
Zygotene/Zygonema
would result to a crossing over or
an exchange of genetic material
between the maternal and paternal
homologous chromosomes
Pachytene/Pachynema
sub-stage where the egg cell
will stop dividing for the first
time.
Diplotene/Dictyate
This is
the movement or
parting of two
strands.
Diakinesis
The daughter cell that
receives little amount of
cytoplasm is called
a polar body and dies via atresia
Has a similar process as mitosis.
MEIOSIS II
the characteristic of the genetic material and end progeny are
halved and doubled, respectively.
MEIOSIS II
MEMORIZE!
*Before M1 – parent cell is diploid (44
chromosomes + 2 allosomes)
*After M1 – daughter cells are haploid (22 chromosomes + 1 allosome)
*Interkinesis
*After M2 – daughter cells are haploid
(22chromatids + 1⁄2 allosome)
MEMORIZE!
*Before M1 – parent cell is diploid (44
chromosomes + 2 allosomes)
*After M1 – daughter cells are haploid (22 chromosomes + 1 allosome)
*Interkinesis
*After M2 – daughter cells are haploid
(22chromatids + 1⁄2 allosome)
is a cell division that produces two diploid cells
Mitosis
involves two cell divisions and produce 4 haploid cells
Meiosis
Process of generating female
seed
OOGENESIS
Process starts from the 5th month of gestation to up to 44
years of age
OOGENESIS
From the Greek words
* -___ meaning a process or a
condition or a status
* -___ meaning female seed
* -___ meaning to come
up with or to produce
osis
osis
genan
34-35 days to complete PGCs come from epiblasts that fail to undergo gastrulation (the process by which epiblasts differentiate into the three different germ layers, the ectoderm, endoderm and the mesoderm)
Oocytogenesis
is required to overcome the first arrest state and to resume meiosis I
Puberty
happens regularly monthly for regularly menstruating
females
Ovulation
Process of expulsion or extrusion of maturing egg cells
from the flesh of the ovary to the Fallopian tube’s ampulla
through the stigma
Ovulation
Starts at age 9 and ends at 44
Ovulation
Last cellular checkpoint if egg cell achieved full maturation
Fertilization
Requires only 74 days for each cycle
SPERMATOGENESIS
No arrest, progeny of spermatid
Meiosis II
13 days to 22 days because of arrest state
Spermatidogenesis
- process takes 4 days
Spermatocytogenesis
- Spermatid to sperm like and 13.5 days
Spermiogenesis
- Immature, immotile,incapableof fertilization
Spermiation
Act of releasing mature, motile, but incapable of fertilization sperm cells
Ejaculation
Period of conditioning
Capacitation
Nourish the PGC from 3rd week to year 10
SERTOLI CELLS
Participate in the blood-testis barrier
SERTOLI CELLS
Synthesis of androgen-binding protein
SERTOLI CELLS
Synthesis of inhibin
Synthesis of anti-Mullerian Hormone or Mullerian
inhibitin substance
SERTOLI CELLS
testosterone/androgen as early as 8th week of gestation;
LEYDIG CELLS