GENETICS Flashcards
Genetics derived from the word gene which means
To become and to grow into
What makes u unique, or one of a kind
Genetics
Why family members look alike
Genetics
Why some disease like diabetes or cancer run in families
Genetics
Proposed the theory that a moist vapor descends from the brain and nerves
Pythagoras
That each parent produce a semen which arises directly from various parts of the body
Empedocles
Though that the vitalizing effect considered as highly purified blood
Aristotle
According to him the mother furnishes innert matter, and the father gives the life giving power, “dynamic to the new life
Aristotle
He believed that the inheritance was conveyed via blood
Aristotle and the reason why people still refer to “blood relatives”“blood lines” and offspring as products of their “flesh and blood”
Preformation theory was proposed by two dutch biologist
Swammerdam and Bonet (1720-1793)
The preformation theory state that a miniature human was already perform in egg and sperm
Homunculus
This theory was rejected because this could not be proved scientifically
Preformation theory
THEORY OF EPIGENETICS was proposed by a German biologist and it states that egg or sperm cells do not contain miniature human but that the gametes contained undifferentiated living substance capable of forming the organized body after fertilization.
Wolff, This proposition was called as epigenetic concept
THEORY OF ACQUIRED CHARACTERS was proposed by, a French biologist.
Lamarck (1744-1829)
This theory states that a new character once acquired by an individual shall pass on to its progeny.
Lamarck (1744-1829)
This theory was disproved by Weismann. He cut the tail of mice for successive generations
THEORY OF ACQUIRED CHARACTERS
THEORY OF PANGENES was proposed by and an English naturalist.
Charles Darwin (1809 – 1882)
According to him, each part of the animal body produces a minute copy of its own, called
gemmule or pangene
theory of pangenesis is also known as the
“theory of blending inheritance”
He developed the theory of natural selection
Charles Darwin (1809 – 1882)
the idea that members of a population who are better adapted to their environment will be the ones most likely to survive and pass their traits on to the next generation.
theory of natural selection,
On the Origin of Species by Means of Natural Selection (1859)
Charles Darwin (1809 – 1882)
GERMPLASM THEORY this theory was advocated by and a German biologist.
August Weismann (1834-1914),
According to this GERMPLASM THEORY, organism’s body contains two types of cells namely
somatic cells and reproductive cells
form the body and its various organ systems
somatic cells
form sperm and ova
reproductive cells
The somatic cells contain the
“somatoplasm”
reproductive cells contain the
“germplasm”
___ which were caused by the environment, cannot influence the germplasm and hence acquired characters are not inherited
(somatoplasm),
Before Mendel’s experiment and ideas, Genetics was
poorly understood
conducted experiments on pea much before Mendel but failed to formulate the laws of inheritance because he could not use the mathematics to his results.
Knight (1779)
a German botanist performed hybridization experiments in tobacco and compared the hybrids with their parents. He demonstrated that the hybrids may resemble one or the other parent or may be intermediate between them. He also showed that both the parents make equal contributions to the hybrids.
J. Kolreuter (1733-1806),
done experiments similar to Kolreuter and they observed the similar results.
Gartner (1772-1850) and Naudin (1815-1899)
developed the understanding genetics by experimenting garden peas (Pisum sativum).
Gregor Mendel
Father of Modern Genetics
Gregor Mendel
Austrian biologist, meteorologist, and Augustinian Priest
Gregor Mendel
wherein he showed that “factors of inheritance” are transferred from parents to offspring.
Gregor Mendel
because they are easy to grow, easy to artificially hybridize (self-pollinating plants), has a short life cycle, with many offsprings in a single cross, and the presence of contrasting traits (alleles), and his use of pure breeds
(Pisum sativum)
responsible for observable characteristics
genotype
as result of fertilization
phenotype
According to Mendel, genetic material of organisms exist in pairs
alleles
A string of complex molecules called
nucleotides
It contains the genetic information of life andacts as a set of instructions for how to build and maintain you.
nucleotides
DNA is found in the heart of almost every human cell, in an area called
nucleus
is unique, unless you’re an identical twin.
DNA
A short section of DNA
GENE
instructions that our cells use to make molecules called
proteins
To strengthen them and keep them safe DNA is looped and coiled into a structure
chromosome
(23 from dad and 23 from mom)
46 Chromosomes
are formed before cells divide.
Chromosomes
one is an exact copy of other and each contains one DNA molecule
Two identical chromatids
short arm structure
p arm
constricted point of the chromosome
centromere
long arm structure
q arm
long string like dna molecule formed into a compact
DNA molecule
xx
xy
female
male
An organism’s complete set of DNA
GENOME
An individual inherits two alleles for each gene, one from each parent
ALLELES
same two copies of a genes
homozygous
different copies of a gene
heterozygous
set of genes in our DNA which is responsible for a particular trait.
GENOTYPE
physical expression, or characteristics, of that trait.
PHENOTYPE
PP and pp are alleles of the pea plant flower color.
GENOTYPE
PP is for purple flowers, pp is for white flowers.
PHENOTYPE
The allele that is expressed and overrules the recessive gene. Denoted by using capital letters.
dominant
Example traits: Dark hair, Curly hair, Baldness, Widow’s peak, Freckles, Right handedness
dominant
are expressed only if both the connected alleles and Denoted by using lower case letter
recessive
Example traits: Blonde or red hair, Straight hair, Straight hairline, Round eyes, Left handedness, Blue eyes
recessive
which is the transmission of genetic material from one generation to the other.
TRANSMISSION GENETICS/ CLASSICAL GENETICS
Focuses on individual organisms and emphasize the relationship between chromosomes and heredity, arrangement of genes on chromosomes, and gene mapping.
TRANSMISSION GENETICS/ CLASSICAL GENETICS
Study on the chemical nature (structure and function) of genes
MOLECULAR AND BIOCHEMICAL GENETICS
Emphasize on how genetic information is encoded, replicated and processed.
MOLECULAR AND BIOCHEMICAL GENETICS
Study of behavior and effects of genes in population, often using mathematical models
POPULATION AND BIOMETRICAL GENETICS
Focuses on the group of genes found in a population and emphasizes on how genetic composition of a group changes over time.
POPULATION AND BIOMETRICAL GENETICS
Studies the influence of varying genetics on animal behavior, the effects of human disorders as well as its causes;
BEHAVIORAL GENETICS
counseling of patients with genetic disorders or syndromes
CLINICAL GENETICS
whose genome has been altered by the introduction of one or more foreign DNA
TRANSGENIC
Provide some synthetically produced raw materials for industries
INDUSTRY
Genetic fingerprinting
* Forensic of crime scene
* Detection of mother and father of fetus
FORENSIC SCIENCES
Does not involve any direct manipulation of genetic material
non-genetically modified (non-GMO).
This method can be used to combine (or splice) DNA from different species or to create genes with new functions.
Recombinant DNA technology
manipulate and isolate DNA segments of interest
Recombinant DNA technology
applied to make important proteins used in the treatment of human diseases, such as insulin and growth hormone
Recombinant DNA technology
mutate the DNA in a way that stops the gene’s expression permanently.
Gene knockout
damage specific genes, making them non-functional.
Gene knockout
Increase understanding of how diseases occur.
Stem cells
Generate healthy cells to replace cells affected by disease (regenerative medicine).
Stem cells
Test new drugs for safety and effectiveness.
Stem cells
an organism that is a product of genetic engineering
Genetically Modified Organism (GMO)
Any organism that has the genetic material from some other organism.
Transgenic
vehicle for transferring the recombinant DNA (altered genetic material) into the organism of interest. Ex. Plasmid and Viruses
Vector
a circular DNA usually found in bacteria and yeast, commonly used for genetic engineering.
Plasmid
Genetic engineering, sometimes called
genetic modification
is the process of altering the DNA in an organism’s genome using biotechnology tools or techniques.
Genetic engineering
CRISP
Clustered Regularly Interspaced Short Palindromic Repeats
is a gene-editing technology that targets specific stretches
“CRISPR-Cas9”
is guided with specific guide RNA to cut at points around specific target
Cas9
is a new type of rice that contains beta carotene
Golden Rice
GENETIC ENGINEERING APPLICATION
- MEDICINE
- AGRICULTURE
- RESEARCH
is the first cloned sheep using nuclear transfer
Dolly the sheep