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BCR 1 > Pharmacology - Pharmacology of respiratory drugs 2 > Flashcards

Pharmacology - Pharmacology of respiratory drugs 2 Flashcards

1
Q

A preventable and treatable disease of airflow limitation not fully reversible,
usually progressive and associated with an abnormal inflammatory response
To noxious gases or particles, may be associated with other extrapulmonary effects

refers to what condition?

a. asthma
b. copd
c. emphysema

A

b.copd

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2
Q

whats the biggest risk factor for COPD?

a. hypertension
b. obesity
c. smoking

A

c.smoking

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3
Q

a chronic productie cough is common in ..

a. asthma
b. copd

A

b.copd

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4
Q

persistent and progressive breathlessness is associated with?

a. copd
b. asthma

A

a.copd

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5
Q

night time waking with wheeze/breathlessness is associated with

a. asthma
b. copd

A

b.copd

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6
Q

15 minutes after
bronchodilator
if FEV1/FVC <0.7 what diagnosis is most likely?

a. copd
b. asthma
c. cf
d. bronchiectasis

A

a.copd

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7
Q 
Steroid reversibility testing: 
- ICS for (6-8 weeks) may 
be undertaken with repeat 
spirometry 
a >12 % increase indicates in which values ....

a. FEV1/FVC ratio
b. FVC
c. FEV1

A

c.FEV1

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8
Q

what grade is dyspnoea only on strenuous excercise

a. 1
b. 2
c. 3
d. 4

A

a.1

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9
Q

what grade is dyspnoea when hurrying /walking up slight hill

a. 1
b. 2
c. 3
d. 4

A

b.2

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10
Q

what grade is dyspnoea when on level ground/ has to stop for breath walking at own pace

a. 1
b. 2
c. 3
d. 4

A

c.3

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11
Q

what grade is dyspnoea involving stopping for breath after walking 100m /a few minutes

a. 1
b. 2
c. 3
d. 4

A

d.4

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12
Q

what grade is dyspnoea involving being too breathless to leave the house /breathlessness when dressing

a. 1
b. 2
c. 3
d. 4
e. 5

A

e.5

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13
Q

whats the first stage of copd management?

a. smoking cessation
b. pneumococcal and flu vaccines
c. pulmonary rehab
d. self management plan

A

a. smoking cessation

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14
Q

what should be started following

a. smoking cessation
b. pneumococcal and flu vaccines
c. pulmonary rehab
d. self management plan
and treatment for comorbitities

A

inhaled therapies

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15
Q

what is the best form of nicotine replacement therapy/

a. patch and inhaler
b. lozenge
c. spray
d. patch

A

a.patch and inhaler

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16
Q

which of these is a nicotinic receptor partial agonist?

a. varenicline
b. bupropion

A

a.varenicline

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17
Q

which of these is a selective neuronal reuptake of catecholamine inhibitor

a. varenicline
b. bupropion

A

b.bupropion

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18
Q

what value is most affected in smokers?

a. FVC
b. FEV1
c. vital capacity

A

b.FEV1

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19
Q

which inhaled therapies should be offered first in copd/

a. SABA/SAMA
b. LABA/LAMA
c. corticosteroids

A

a.SABA/SAMA

20
Q

if patient still breathless following SABA/SAMA and has no asthmatic features /features suggesting steroid response what should be offered/

a. LAMA+LABA+ICS
b. LABA/LAMA
c. corticosteroids
d. LABA+LAMA
e. LABA+ICS

A

d.LABA+LAMA

21
Q

if patient still breathless following SABA/SAMA and has asthmatic features /features suggesting steroid response what should be offered/

a. LAMA+LABA+ICS
b. LABA/LAMA
c. corticosteroids
d. LABA+LAMA
e. LABA+ICS

A

e.LABA+ICS

22
Q

if patient still breathless following LABA +ICS and is still breathless/ has exacerbations what should be offered?

a. LAMA+LABA+ICS
b. LABA/LAMA
c. corticosteroids
d. LABA+LAMA
e. LABA+ICS

A

a.LAMA+LABA+ICS

23
Q

what is essential for all inhaled therapies

A

patient training

24
Q

what informs COPD management?

a. QRISK 3
c. GRACE
d. GOLD

A

d.GOLD

25
Q

what does oral roflumilast inhibit?

a. phosphodiesterase 4
b. phosphodiesterase 1
c. phosphodiesterase 2

A

a. phosphodiesterase 4

26
Q

how often should roflumilast be taken?

a. once weekly
b. once daily
c. twice daily

A

b.once daily

27
Q

what effect does roflumilast have on CAMP?

a. decrease
b. increase

A

b.increase

anti inflam

28
Q

roflumilast reduces recruitment of which cells?

a. basophils and eosinophils
b. neutrophils and basophils
c. neutrophils and eosinophils

A

c.neutrophils and eosinophils

29
Q

in severe copd (FEV1<50%) and 3+ exacerbations in prev 12 months despite ICS+LAMA+LABA what should be given as add on?

a. SAMA
b. SABA
c. roflumilast

A

c.roflumilast

30
Q

whats the main adverse effect of roflumilast?

a. diarrohea
b. weight loss
c. nausea
d. headache

A

a.diarrohea

31
Q

roflumilast should be taken with caution in patients with..

a.psychiatric illness
b.obesity
c,hypertension
d.elderly

A

a.psychiatric illness

32
Q

which of these is a mucolytic agent?

a. roflumilast
b. Muscarinic antagonist
c. carbocysteine

A

c. carbocysteine

33
Q

carbocysteine reduces hypersecretion of what by mucus cells in response to irritants?

a. proteins
b. glycoproteins
c. lipids

A

b.glycoproteins

34
Q

what is given as an oral capsule for copd with excessive viscous mucus?

a. roflumilast
b. Muscarinic antagonist
c. carbocysteine

A

c. carbocysteine

35
Q

which of these should be avoided in active peptic ulcer disease?

a. roflumilast
b. Muscarinic antagonist
c. carbocysteine

A

c. carbocysteine

36
Q

PEFR >75% previous best/predicted

a. mild asthma
b. moderate asthma
c. severe asthma
d. life threatening asthma

A

a.mild asthma

37
Q

PEFR 50-75% previous best/predicted

a. mild asthma
b. moderate asthma
c. severe asthma
d. life threatening asthma

A

b.moderate asthma

38
Q

PEFR <50% previous best/predicted

a. mild asthma
b. moderate asthma
c. severe asthma
d. life threatening asthma

A

c.severe asthma

39
Q

PEFR <33% previous best/predicted

a. mild asthma
b. moderate asthma
c. severe asthma
d. life threatening asthma

A

d.life threatening asthma

40
Q

IV magnesium sulphate can be considered in..

a,mild asthma

b. mild-moderate asthma
c. moderate to severe asthma
d. severe - life threatening

A

d.severe - life threatening

41
Q

what is given every 15-20 mins in acute exacerbation of asthma?

a.stat nebulised salbutamol SABA 5mg

b. STAT steroid prednisolone
40mg oral // hydrocortisone 100 mg IV regular dose for 7 days

c. STAT nebulised ipratropium bromide
d. call 99
e. IV magnesium sulfate

A

a.stat nebulised salbutamol SABA 5mg

42
Q

what is given after stat nebulised salbutamol 5 mg in acute asthma exacerbation?

a.stat nebulised salbutamol SABA 5mg

b. STAT steroid prednisolone
40mg oral // hydrocortisone 100 mg IV regular dose for 7 days

c. STAT nebulised ipratropium bromide
d. call 99
e. IV magnesium sulfate

A

b. STAT steroid prednisolone

40mg oral // hydrocortisone 100 mg IV regular dose for 7 days

43
Q

what is given after stat nebulised salbutamol 5 mg requires repeated use in acute asthma exacerbation?

a.stat nebulised salbutamol SABA 5mg

b. STAT steroid prednisolone
40mg oral // hydrocortisone 100 mg IV regular dose for 7 days

c. STAT nebulised ipratropium bromide 500 micrograms (SAMA)
d. call 99
e. IV magnesium sulfate

A

c. STAT nebulised ipratropium bromide 500 micrograms

44
Q

what should be stopped while on stat nebulised ipratropium bromide 500 mg (SAMA)

a.LABA
b.SABA
c.SAMA
D.LAMA

A

D.LAMA

45
Q

what is offered first in end stage copd?

a. Non invasive ventilation
b. long term oxygen therapy
c. opiods for dyspnoea
d. macmillan

A

.Non invasive ventilation

46
Q

what is offered second in end stage copd?

a. Non invasive ventilation
b. long term oxygen therapy
c. opiods for dyspnoea
d. macmillan

A

b. long term oxygen therapy

BCR 1 (60 decks)

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