PATHOMA- JOINTS Flashcards
Chronic, systemic, autoimmune disorder
Affects mostly middle aged women
HLA-DR4
RA
Halmarks of RA
synovitis with pannus formation
destruction of cartilage
possible osteopenia
Pannus and it’s problems
thickening of the synovium leads to joint space narrowing loss of cartilage joint deviations ankalyzing
Clinical picture of RA
Morning stiffness- better with activity
symmetric joint involvement
DIPs are spared
may have: lymphandopathy, interstitial lung fibrosis
Lab findings of RA
RF
inc. neuts and protein in synovial fluid
anemia of chronic disease
No RF
Axial skelto
HLA B27
seronegative spondyloarthropathy
No RF (seronegative) Axial skelton (spondylo)
seronegative spondyloarthropathy presentation
Usually in males presents as low back pain vertebra may fuse uveitis high risk for anyrism
Conjunctivitis
urethritis
arthritis
onset after GI/Chlamydia infcetion
Reiter syndrome- seronegative spondyloarthropathy
Can’t see, can’t pee, can’t climb a tree
Reiter syndrome clinical picture
10% w/psoriasis
axial/perf joint. Affects DIPs
“sausage digits”
Caused in young adults Gonorrhea
in Adults/Kids by S. Aureas
usually single, warm joint with systemic symptoms
Infections Arthritis
Deposition of MSU crystals in the tissue
due to hyperuricemia
Gout
hyperuricemia causes
increased production
decreased removal
Unknown cause of hyperuricemia
usually in adult males
Primary Gout
Secondary causes of gout
leukemia
MPD
Lesh Nynn
Renal insufic
painful arthritis of great toe
crystals activate neurtophils
Triggers are ETOH and meat
Acute Gout
