PATHOMA- JOINTS

Question 1

Chronic, systemic, autoimmune disorder
Affects mostly middle aged women
HLA-DR4

Answer 1

RA

Question 2

Halmarks of RA

Answer 2

synovitis with pannus formation
destruction of cartilage
possible osteopenia

Question 3

Pannus and it’s problems

Answer 3

thickening of the synovium 
leads to joint space narrowing 
loss of cartilage 
joint deviations
ankalyzing

Question 4

Clinical picture of RA

Answer 4

Morning stiffness- better with activity
symmetric joint involvement
DIPs are spared

may have: lymphandopathy, interstitial lung fibrosis

Question 5

Lab findings of RA

Answer 5

RF
inc. neuts and protein in synovial fluid
anemia of chronic disease

Question 6

No RF
Axial skelto
HLA B27

Answer 6

seronegative spondyloarthropathy

No RF (seronegative) 
Axial skelton (spondylo)

Question 7

seronegative spondyloarthropathy presentation

Answer 7

Usually in males
presents as low back pain
vertebra may fuse
uveitis 
high risk for anyrism

Question 8

Conjunctivitis
urethritis
arthritis
onset after GI/Chlamydia infcetion

Answer 8

Reiter syndrome- seronegative spondyloarthropathy

Can’t see, can’t pee, can’t climb a tree

Question 9

Reiter syndrome clinical picture

Answer 9

10% w/psoriasis
axial/perf joint. Affects DIPs
“sausage digits”

Question 10

Caused in young adults Gonorrhea
in Adults/Kids by S. Aureas

usually single, warm joint with systemic symptoms

Answer 10

Infections Arthritis

Question 11

Deposition of MSU crystals in the tissue

due to hyperuricemia

Answer 11

Gout

Question 12

hyperuricemia causes

Answer 12

increased production

decreased removal

Question 13

Unknown cause of hyperuricemia

usually in adult males

Answer 13

Primary Gout

Question 14

Secondary causes of gout

Answer 14

leukemia
MPD
Lesh Nynn
Renal insufic

Question 15

painful arthritis of great toe
crystals activate neurtophils
Triggers are ETOH and meat

Answer 15

Acute Gout

Question 16

Tophi

Renal Failure

Answer 16

Chronic gout

Question 17

Tophi are

Answer 17

uric acid crystals in soft tissue or joints

may have fibrosis

Question 18

Renal Failure from chronic gout is caused by

Answer 18

Uric acid deposits in the kidney

Question 19

Gout Labs

Answer 19

hyperglycemia

yellow needle shaped crystals

Question 20

______ resembles gout

Answer 20

pseudogout

Question 21

Dermatomyositis

Answer 21

proximal muscle weakness
malar rash
gortons lesions
helitrope rash

Question 22

Dermatomyositis lab findings

Answer 22

inc. CPK
+ana w/ Anti-Jo1
perimysial inflamation

Question 23

Polymyositis vs Dermatomyositis

Answer 23

no skin findings

invades endomysium

Question 24

Lipoma

Answer 24

tumor of the adipose tissue