BL- RA Flashcards
secondary causes of hyperuricemia in normal uric acid metabolism
a
RHEUMATOID ARTHRITIS
Articular manifestations
Joint distribution 1
Predominantly peripheral synovial joints in a symmetric pattern, particularly the small joints of the hands and feet, although medium and large joints are also involved.
DIP often spared.
Rheumatoid arthritis (RA) is a systemic, inflammatory, autoimmune disorder of unknown etiology that results predominantly in a peripheral, symmetric, inflammatory synovitis often leading to:
cartilage and bone destruction and joint deformities
RHEUMATOID ARTHRITIS
Articular manifestations
Joint distribution 2
Cervical spine also commonly involved (usually C1-2)
Other synovial joints may be involved including the cricoarytenoid, ossicles of inner ear, and temporomandibular joint.
Rheumatoid arthritis (RA) is a ______________ disorder of unknown etiology that results predominantly in a peripheral, symmetric, inflammatory synovitis often leading to cartilage and bone destruction and joint deformities
systemic, inflammatory, autoimmune
Joint spared in RA?
DIPs
RHEUMATOID ARTHRITIS
Articular manifestations
Symptoms
Morning stiffness, soft tissue swelling around joints, and pain.
Deformities and loss of function possible.
Rheumatoid arthritis (RA) is a systemic, inflammatory, autoimmune disorder of unknown etiology that results predominantly in a __________ often leading to cartilage and bone destruction and joint deformities
peripheral, symmetric, inflammatory synovitis
RHEUMATOID ARTHRITIS
Articular manifestations
Signs
Joint warmth and swelling
Tenderness to palpation with limitation of motion.
Possible deformities may be present.
Serologic findings RA Rheumatoid factor (RF) is present in \_\_\_\_\_\_.
85%
Serologic findings RA
_______proteins often elevated.
ESR or C-reactive
Anemia and ______are frequently found in RA
hypergammaglobulinemia
Anti-cyclic citrullinated peptide (CCP) antibodies present in ______: Anti-CCP antibodies are highly specific (specificity > 90%) for RA.
70%
______ and hypergammaglobulinemia are frequently found in RA
Anemia
Anti-cyclic citrullinated peptide (CCP) antibodies present in 70%: Anti-CCP antibodies are highly_______
specific (specificity > 90%) for RA.
Synovial fluid analysis RA
Inflammatory (>2000 WBC/microliter) with predominantly neutrophils.
Complement and glucose levels usually low.
Radiographic findings RA
Soft tissue swelling.
Juxta-articular osteopenia.
Symmetric loss of joint space.
Erosions in marginal distribution.
Rheumatoid nodules
Present in 20-25%, associated with presence of serum RF.
Location: extensor surfaces and tendon sheaths.
May be present in a variety of internal organs, particularly lung.